This study compared central and peripheral fatigue development between the Sprint and Olympic distance triathlon. Fifteen male triathletes performed Sprint and Olympic triathlon simulations in a randomized and counterbalanced order. Central and peripheral fatigue was evaluated from changes in voluntary activation level (VAL) and twitch responses of quadriceps muscle (Q), respectively. Q reduced from baseline to post-swimming similarly between triathlon simulations (Sprint,-1711%; Olympic, -139%). In post-cycling, Q further declined to a similar extent between triathlon distances (Sprint, -3115%; Olympic, -2811%). In post-running, Q was fully recovered in the Olympic triathlon (-410%), whereas there was only a partial recovery of Q in the Sprint triathlon (-2011%). VAL was not reduced in post-swimming, but reduction was similar between triathlon distances in post-cycling (Sprint, -109%; Olympic, -88%) and post-running (Sprint, -1514%; Olympic, -168%). In the Sprint triathlon, the swimming speed (1.070.13m.s) was above ( .001) critical speed (1.010.14m.s), the cycling power (179.727.2W) was below the respiratory compensation point (216.327.8W, .001) and running speed (13.71.05km.h) similar to the respiratory compensation point (13.20.70km.h, .124). In the Olympic triathlon, swimming speed (1.030.13m.s) was similar to critical speed ( .392), and cycling power (165.327.3W) and running speed (12.61.05km.h) were below the respiratory compensation point ( .007). In conclusion, peripheral fatigue progressed until post-cycling regardless of triathlon distances. However, peripheral fatigue was fully recovered after running in Olympic but not in Sprint triathlon. The central fatigue started in post-cycling and progressed until post-running regardless of triathlon distances.The quadriceps muscle peripheral fatigue progresses similarly in Sprint and Olympic triathlons until post-cycling.The quadriceps muscle peripheral fatigue is completely recovered after running in the Olympic triathlon, whereas it is partially recovered in the Sprint triathlon.The central fatigue starts in post-cycling and progresses similarly until post-running in Sprint and Olympic triathlons, regardless of triathlon distances.
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http://dx.doi.org/10.1080/17461391.2022.2072772 | DOI Listing |
Lupus Sci Med
January 2025
School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK
Introduction: SLE is a chronic autoimmune disease that results in sustained hyperactivation of innate and adaptive immune cells and widespread inflammatory damage. Regular exercise reduces SLE symptoms including fatigue and joint pain and improves patient quality of life. However, most individuals with SLE are not sufficiently active to achieve these benefits, and guidance on the optimal approach to exercise is limited.
View Article and Find Full Text PDFJ Reprod Immunol
January 2025
Department of Biomedical Sciences and Institute for Medical Science, Jeonbuk National University Medical School, Jeonju 54907, South Korea. Electronic address:
Endometriosis (EMS) is a prevalent gynecological condition characterized by the presence of endometrial tissue outside the uterus, often leading to secondary dysmenorrhea (SD), chronic pelvic pain and infertility. This review explores the intricate connection between EMS- associated pain and SD, focusing on the pathophysiological mechanisms underlying dysmenorrhea in EMS. Key contributors to pain include inflammation, aberrant immune responses, neurogenic inflammation, peritoneal irritation, peripheral sensitization, central sensitization and cross-organ sensitization.
View Article and Find Full Text PDFTransl Pediatr
December 2024
Department of Infectious Diseases, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Chronic active Epstein-Barr virus (CAEBV) infection is a rare disease in which the Epstein-Barr virus (EBV) persists and replicates, causing chronic symptoms and fatal complications. The treatment of CAEBV is still evolving. Our case report showed a new therapy for CAEBV.
View Article and Find Full Text PDFArch Rehabil Res Clin Transl
December 2024
Peninsula Hospital Center, Department of Speech-Language Pathology and Audiology, Far Rockaway, NY.
Objective: To determine if fatigue systematically effects the timing of swallowing events and to discuss underlying causes of fatigue other than peripheral neuromuscular fatigue.
Design: Pre-post within-subject repeated-measures design.
Setting: General acute care hospital and designated stroke center.
Clin Exp Immunol
January 2025
Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Introduction: Multiple Sclerosis (MS) is a complex auto-inflammatory disease affecting the brain and spinal cord, which results in axonal de-myelination and symptoms including fatigue, pain, and difficulties with vision and mobility. The involvement of the immune system in the pathology of MS is well established, particularly the adaptive T cell response, and there has been a particular focus on the IL-17-producing subset of Th17 cells and their role in driving disease. However, the importance of innate immune cells has not been so well characterised.
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