AI Article Synopsis
- The article discusses a pilot study examining the gut microbiome diversity and metabolic potential in adolescents with functional bowel disorders compared to healthy individuals.
- Using advanced metagenomic sequencing techniques, researchers found distinct differences in the gut microbiome's composition between those with functional bowel disorders and the control group.
- The study also revealed that adolescents could be classified into two groups based on their metabolic potential, indicating variations in amino acid and lipid biosynthesis metabolism regardless of their specific bowel disorder symptoms.
Article Abstract
The article presents the results of a pilot study of the diversity and metabolic potential of the gut microbiome in adolescents with various forms of functional bowel disorder. The participants were the patients of the Clinic of Research Center for Family Health and Human Reproduction Problems. Biological material was studied using metagenomic sequencing of V3-V4 variable regions of the 16S rRNA gene. We showed that the composition of the minor component of the intestinal microbiome in adolescents with functional bowel disorder differs from that in the healthy subjects (control). Different types of transit disturbances in functional bowel disorder also differ from each other. According to the metabolic potential, adolescents can be divided into two groups irrespective of the pathophysiological manifestations: for one group, a more intensive metabolism in amino acid and lipid biosynthesis pathways was predicted than for the other.
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| http://dx.doi.org/10.1007/s10517-022-05456-9 | DOI Listing |
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