Background: FokI (rs2228570 T>C) and BsmI (rs1544410 A>G) polymorphisms of the vitamin D receptor (VDR) have been associated to abnormal glucose metabolism and could be inversely associated with β-cell function (BCF) and vitamin D status. There is a lack of information about this topic in the Mexican population.
Aim Of The Study: To evaluate the relationship between VDR gene polymorphisms FokI and BsmI with BCF and vitamin D status in a population of non-obese Mexican adults.
Methods: A sample of 192 participants were enrolled during 2016-2018. Blood samples were collected to determine fasting concentrations of glucose, insulin, and vitamin D. Genomic DNA was isolated from leucocytes and the polymorphic variants of FokI and BsmI were analyzed. The Homeostasis Model Assessment Calculator was used to estimate the BCF (HOMA2-B).
Results: FokI polymorphism showed a frequency of 20.1% for homozygous TT carriers and 7.8% for the BsmI GG. The recessive model of FokI (TT genotype) showed a lower mean value of BCF compared to the combination of CC + CT (99.2 vs. 109.6%, p = 0.045). Likewise, significantly lower mean values of HOMA2-B and insulin were observed for BsmI (GG genotype, p = 0.016 and p = 0.039, respectively). After covariates adjustment, only FokI polymorphism remained as an independent predictor of BCF.
Conclusions: the TT and GG variants of the FokI and BsmI polymorphisms are related to a decrease in FCB. In the case of FokI, this decrement was independent of insulin sensitivity, vitamin D levels, percentage of body fat, gender, and age.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.arcmed.2022.04.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Correlation of vitamin D with glucose-lipid metabolism and nutritional status in patients with newly diagnosed type 2 diabetes mellitus.
Pak J Pharm Sci
January 2025
School of Pharmacy, Shaoyang University, Shaoyang, Hunan, China.
Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases worldwide, with no cure at present. Vitamin D (VD) is a fat-soluble vitamin, which has been recognized as one of the major influencing factors of T2DM. However, the specific relationship between T2DM and VD remains elusive.
View Article and Find Full Text PDFNutrient Intake and Dietary Adequacy Among Rural Tanzanian Infants Enrolled in the Mycotoxin Mitigation Trial.
Nutrients
December 2024
Division of Nutritional Sciences, Cornell University, 244 Garden Ave, Ithaca, NY 14853, USA.
Background: The Mycotoxin Mitigation Trial (MMT) was a community-based cluster-randomized trial designed to assess the effect of dietary aflatoxin (AF) on linear growth. Similar dietary intake between arms was an important component of the trial's program theory and essential for the trial's internal validity and interpretation.
Objective: This analysis assessed and compared dietary intake by arm within a sub-sample of infants enrolled in the MMT.
Relationship Between Vitamin D Levels with In-Hospital Complications and Morphofunctional Recovery in a Cohort of Patients After Severe COVID-19 Across Different Obesity Phenotypes.
Nutrients
December 2024
Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital University Hospital, 29010 Málaga, Spain.
Background And Objectives: the COVID-19 pandemic underscored the necessity of understanding the factors influencing susceptibility and disease severity, as well as a better recovery of functional status, especially in postcritical patients. evidence regarding the efficacy of vitamin D supplementation in reducing the severity of COVID-19 is still insufficient due to the lack of primary robust trial-based data and heterogeneous study designs. the principal aims of our study were to determine the impact of vitamin D deficiency or insufficiency on complications during intensive care unit (icu) stay, as well as its role in muscle mass and strength improvement as well as morphofunctional recovery during a multispecialty 6-month follow-up program based on adapted nutritional support and specific physical rehabilitation.
View Article and Find Full Text PDFDietary Nutrient Adequacy in Aeronautical Military Personnel in Spain: Strengths and Weaknesses.
Nutrients
December 2024
Grupo de Investigación Consolidado "Alimentación y Nutrición en la Promoción de la Salud" (CEU-NutriFOOD), Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, Spain.
Background/objectives: Aeronautical military personnel operate under intense physical and mental stress, requiring high psychophysical aptitude. Adequate nutrition is essential to sustain operational readiness and mitigate the risk of chronic diseases and other health issues. This study aims to evaluate the nutritional status of aeronautical military personnel group in Spain through dietary parameters.
View Article and Find Full Text PDFThe Physical Developmental Characterization of Children with Nutritional Deficiencies and Attributed Specific Categories.
Nutrients
December 2024
Department of Social Medicine, School of Public Health, Harbin Medical University, Harbin 150081, China.
Background: There are few studies examining the physical developmental phenotypes of nutritional deficiency diseases (NDDs) among Chinese children aged 1-7 years by anthropometrics and clarifying the specific NDD categories that caused growth faltering.
Methods: A total of 3054 cases of NDDs in children aged 1-7 years were investigated. The age, height, and weight of children with NDDs were adjusted by using the skewness coefficient-median-coefficient of variation method, and the results were compared with the WHO standardized level.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!