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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067383 | PMC |
| http://dx.doi.org/10.1503/cmaj.210981 | DOI Listing |
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Elevated Hemoglobin A1c and the Risk of Developing ARDS in Two Cohort Studies.
CHEST Crit Care
September 2024
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.
Article Synopsis
- The study investigates the link between long-term blood glucose levels (measured by hemoglobin A1c, HbA1c) and the development of Acute Respiratory Distress Syndrome (ARDS) among critically ill adults who are at risk for ARDS.
- It analyzes data from two cohorts, finding that patients with diabetes did not have a significantly higher risk of ARDS compared to nondiabetics; however, those with poorly controlled diabetes (high HbA1c) had an increased risk.
- While the findings were not consistent across both cohorts, the combined analysis suggests that high HbA1c levels could indicate an elevated risk for ARDS, particularly in patients with diabetes.
A Rare Case of Multiple Bone Infarctions and Abnormal Pulmonary Function Tests in a Patient With Compound Heterozygous Hemoglobin S and Type 2 Hereditary Persistence of Fetal Hemoglobin.
Cureus
August 2024
Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, ARE.
Sickle cell disease (SCD) is a group of inherited blood disorders characterized by abnormal hemoglobin production, affecting individuals worldwide with varying prevalence across different populations. Manifestations vary, ranging from severe to mild. SCD is characterized by the presence of hemoglobin S (HbS), which distorts erythrocytes upon deoxygenation, leading to sickling.
View Article and Find Full Text PDFGlobal Transcriptomic and Characteristics Comparisons between Mouse Fetal Liver and Bone Marrow Definitive Erythropoiesis.
Cells
July 2024
Laboratory of Membrane Biology, New York Blood Center, New York, NY 10065, USA.
Erythropoiesis occurs first in the yolk sac as a transit "primitive" form, then is gradually replaced by the "definitive" form in the fetal liver (FL) during fetal development and in the bone marrow (BM) postnatally. While it is well known that differences exist between primitive and definitive erythropoiesis, the similarities and differences between FL and BM definitive erythropoiesis have not been studied. Here we performed comprehensive comparisons of erythroid progenitors and precursors at all maturational stages sorted from E16.
View Article and Find Full Text PDFScreening for undiagnosed pancreatic exocrine insufficiency (PEI) in a cohort of diabetic patients using faecal elastase testing and PEI scoring system.
Acta Diabetol
October 2024
Department of Gastroenterology, Tallaght University Hospital, TallaghtDublin 24, Ireland.
Introduction: Type 1 and type 2 diabetes mellitus (DM) are often accompanied by mild forms of pancreatic exocrine insufficiency (PEI). The prevalence rates of PEI in diabetic patients are unclear and variable depending on the testing modality and the studies published. The clinical consequences of PEI in diabetics are also not well defined.
View Article and Find Full Text PDFStudy of Glycemic Variability in Well-controlled Type 2 Diabetic Patients Using Continuous Glucose Monitoring System.
J Assoc Physicians India
January 2024
Senior Resident, Department of Preventive and Social Medicine, All India Institute of Medical Science (AIIMS), Jodhpur, Rajasthan, India.
Article Synopsis
- - The rise of technologies like continuous glucose monitoring (CGM) and flash glucose monitoring has transformed how patients manage diabetes, allowing them to track glycemic variability (GV), which traditional methods like HbA1c fail to adequately reflect.
- - This study aimed to assess GV in well-controlled type 2 diabetes mellitus (T2DM) patients and its correlation with HbA1c using a flash CGM system.
- - Conducted over 7 days with 30 patients, the research involved monitoring glycemic excursions using the FreeStyle Libre Pro™ and analyzing the data for standard CGM metrics.
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