Age-related macular degeneration (AMD) is a highly prevalent retinal disease in the elderly with a potential deleterious effect on quality of life. Since the introduction of intra-ocular anti-vascular endothelial growth factor (anti-VEGF) injections, wet AMD has become a manageable disease. Unfortunately, not all patients can be managed with existing treatment options. Moreover, frequent injections and control visits place a heavy burden on society and patients. New anti-VEGF are currently being developed which seek to lengthen the time needed between treatments. In addition, home monitoring could dampen costs and lower patient burden. There are hopeful developments underway which seek to slow down the growth rate of geographic atrophy in patients with advanced dry AMD. The increasing number of elderly patients entails that our efforts cannot be solely directed at increasing and optimizing treatment options. A concerted effort must be carried out to limit exposure to modifiable risk factors.
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ACS Nano
March 2025
Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai 200080, China.
Small interfering RNA (siRNA) has garnered tremendous interest as a potential therapeutic tool because of its intriguing gene-silencing ability. Toward the success in the manufacture of siRNA therapeutics for the potential treatment of choroidal neovascularization (CNV), siRNA conjugated with dual functional units of membrane-penetrating heptafluoropropyl and age-related macular degeneration-targeting cyclic Arg-Gly-Asp (RGD) peptide was attempted for transcellular transportation into the cell interiors. Of note, cyclic RGD allowed selective affinities toward the angiogenic endothelial cells in the pathological CNV.
View Article and Find Full Text PDFJpn J Ophthalmol
March 2025
Department of Ophthalmology, Fukushima Medical University, Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan.
Purpose: To assess the short-term changes in intraocular pressure (IOP) following intravitreal injections of aflibercept or faricimab in Japanese patients with neovascular age-related macular degeneration (nAMD).
Study Design: Retrospective observational study.
Methods: This retrospective observational study included 161 eyes from 160 Japanese patients diagnosed with nAMD.
Int Ophthalmol
March 2025
Department of Medicine Surgical, Section of Ophthalmology, University of Perugia, S. Maria Della Misericordia Hospital, 06156, Perugia, Italy.
Purpose: To evaluate the occurrence of complications following intravitreal injections (IVIs) performed in an outpatient clean room (OCR) equipped with the mobile laminar airflow device (LAF) Operio.
Methods: This retrospective study analyzed the data of 10,016 IVIs performed in an OCR from April 2023 to November 2024. All information of each patient was registered, such as diagnosis, drug injected and any occurring complication or adverse events such as endophthalmitis, intraocular inflammation, rhegmatogenous retinal detachment (RRD), vitreous hemorrhages and elevated intraocular pressure.
Acta Ophthalmol
March 2025
Hospital Sagunto, Ophthalmology Service, Sagunto, Spain.
Curr Eye Res
March 2025
McLaughlin Research Institute, Great Falls, MT, USA.
Purpose: This minireview discusses desmosome and hemidesmosome disassembly and/or internalization and subsequent release exosomes in retinal pigmented epithelium (RPE) under oxidative stress conditions, and whether it may be a precursor to epithelial-mesenchymal transition in early Age-related Macular Degeneration (AMD).
Methods: Literature review and discussion of novel findings relevant to the focus of the review.
Results: The RPE forms the outer blood-retinal barrier, and like other epithelia it has several different types of cell-cell junctions, such as desmosomes.
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