A Glucagonoma Presenting as Cerebral Vein Thrombosis and Diabetes.

Case Rep Endocrinol

Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Quebec, Canada.

Published: April 2022

Glucagonomas are rare pancreatic neuroendocrine tumors (pNETs), malignant in 80% of cases, thus highlighting the importance of early diagnosis and treatment. Primary manifestations are diabetes, dermatosis, depression, weight loss, and deep vein thrombosis. Unlike other pNETs, glucagonomas are associated with a higher incidence of thromboembolic events, often resulting in death. We present the case of a glucagonoma patient whose primary manifestation was cerebral sinus venous thrombosis (CS-VT). Early diagnosis enabled curative resection. The purpose of this paper is to review the underlying mechanisms associated with increased coagulopathy in glucagonomas.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054441PMC
http://dx.doi.org/10.1155/2022/7659341DOI Listing

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