The palladium catalyzed aldehyde directed acetoxylation of C(sp)-H bonds was realized by a transient directing group approach for the first time. Crucial to the successful outcome of this reaction is the dual role of acetohydrazide as a directing group for the catalytic C(sp)-H activation process and as a protecting group for the CHO functional group. The applicable methodology exhibits good functional group tolerance and occurs readily under mild conditions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050629 | PMC |
| http://dx.doi.org/10.1039/d0ra01927e | DOI Listing |
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