We have presented an efficient method to access -difluoro-2-trifluromethyl styrene derivatives palladium catalysis. This method features mild reaction conditions, broad substrate scope and good product yields. Moreover, gram-scale reactions demonstrated the robustness and potential of this method. Control experiments revealed that the -CF group was essential to the success of this transformation. Finally, the practicality of this method was successfully proven by three synthetic applications.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049850PMC
http://dx.doi.org/10.1039/d2ra02473jDOI Listing

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