Observations in animal experiments and in Phase I clinical trials on the effect of breathing 8-10% oxygen are summarized. The animal tests indicated that the hypoxia induced in this way for periods varying between 10-45 minutes had a radioprotective effect on normal tissues. Patients tolerated the hypoxic treatment given for 15 minutes without any acute or late complications. Phase II trials have been started to test the effect of hypoxic radiotherapy in administering a larger total tumor dose than in conventional radiotherapy.
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[Hypoxic radiotherapy. The radioprotective effect of acute hypoxia in the radiotherapy of tumors in the abdominal area].
Strahlenther Onkol
December 1994
Klinik und Poliklinik für Strahlentherapie, Universität Erlangen-Nürnberg.
Aim: We tested, whether inhalation a of gas mixture containing 8.0 to 8.5% O2 reduces the radiosensitivity of healthy tissue in order to deliver higher tumor doses without increasing the side effects of radiation therapy.
View Article and Find Full Text PDFObservations in animal experiments and in Phase I clinical trials on the effect of breathing 8-10% oxygen are summarized. The animal tests indicated that the hypoxia induced in this way for periods varying between 10-45 minutes had a radioprotective effect on normal tissues. Patients tolerated the hypoxic treatment given for 15 minutes without any acute or late complications.
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