Photostable near-infrared-absorbing diradical-platinum(ii) complex solubilized by albumin toward a cancer photothermal therapy agent.

RSC Adv

Graduate School of Environmental Studies, Tohoku University 6-6-07, Aramaki-Aoba, Aoba-ku Sendai 980-8579 Japan +81-22-795-7293.

Published: February 2020

A hydrophobic diradical-platinum(ii) complex was solubilized in aqueous solutions by using bovine serum albumin and exhibited photothermal conversion under near-infrared (NIR) light irradiation. The complex was introduced into cancer cells and induced cell death upon absorption of NIR. These results imply that the complex can function as a photothermal therapeutic agent.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049767PMC
http://dx.doi.org/10.1039/d0ra00652aDOI Listing

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