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An analysis of the structural changes of the oxygen evolving complex of Photosystem II in the S and S states revealed by serial femtosecond crystallography.
Biochim Biophys Acta Bioenerg
December 2024
Laboratory of Computational Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:
Photosystem II (PSII) is a unique natural catalyst that converts solar energy into chemical energy using earth abundant elements in water at physiological pH. Understanding the reaction mechanism will aid the design of biomimetic artificial catalysts for efficient solar energy conversion. The MnOCa cluster cycles through five increasingly oxidized intermediates before oxidizing two water molecules into O and releasing protons to the lumen and electrons to drive PSII reactions.
View Article and Find Full Text PDFFinding the E-channel proton loading sites by calculating the ensemble of protonation microstates.
Biochim Biophys Acta Bioenerg
January 2025
Department of Physics, The City College of New York, NY 10031, USA; Graduate Program In Biochemistry, The Graduate Center of CUNY, 365 5th Avenue, NY 10031, USA. Electronic address:
The aerobic electron transfer chain builds a proton gradient by proton coupled electron transfer reactions through a series of proteins. Complex I is the first enzyme in the sequence. Here transfer of two electrons from NADH to quinone yields four protons pumped from the membrane N- (negative, higher pH) side to the P- (positive, lower pH) side.
View Article and Find Full Text PDFAmyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron loss, microgliosis, and neuroinflammation. While pyroptosis, an inflammatory form of programmed cell death, has been implicated in ALS, the specific role of Gasdermin D (GSDMD) - the primary executioner of pyroptosis - remains unexplored. In this study, we examined the function of GSDMD in the well-established SOD1 mouse model of ALS.
View Article and Find Full Text PDFShort QT intervals in African lions.
Exp Physiol
December 2024
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Article Synopsis
- The study investigates the cardiac conduction system in African lions, particularly focusing on differences in QT intervals between wild and zoo-kept lions.
- Researchers recorded ECGs from wild, conscious lions in Africa and compared them to those from anaesthetized zoo lions, hypothesizing that zoo lions would show shorter QT intervals.
- The findings revealed significantly longer QT intervals in wild lions (398 vs. 297 ms), indicating functional differences in cardiac health tied to physical fitness that could impact conservation efforts and veterinary care.
Assignment of chlorophyll d in the Chl site of the electron transfer chain of far-red light acclimated photosystem II supported by MCCE binding calculations.
Biochim Biophys Acta Bioenerg
November 2024
Ph.D. Program in Physics, The Graduate Center, City University of New York, New York, NY 10016, USA; Department of Physics, City College of New York, New York, NY 10031, USA.
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