Site-selective unidirectional benzylic sp C-H oxidation of dodecahydrotriphenylene with RuCl-NaIO: formation of benzylic ketones.

Dodecahydrotriphenylene, a higher homologue of trindane chemoselectively undergoes unidirectional benzylic sp C-H oxidation and the central benzene ring remains intact unlike that in trindane under similar reaction conditions. RuO which generally attacks sp C-H to form oxidative products is found to give benzylic ketones sp C-H oxidation. Density functional theory (DFT) calculations have also been performed to analyse the potential energy, energy barrier and HOMO-LUMO energy gap of the products.