Background And Aim: has long been used for medical purposes in Indonesia. However, reports on the anti-arthritic activities of are limited.
Experimental Procedure: The anti-arthritic properties of an n-hexane-insoluble fraction of dichloromethane extracts of (IPM) were evaluated using Complete Freund's Adjuvant (CFA)-induced arthritis induced in female Wistar rat by CFA. Diclofenac was used as a positive control. The volume of paw oedema, white blood cell count, lymphocytes, neutrophils, expression of TNF-α and Interleukin-6 and the histopathological features of the joint tissues were assessed to characterise IPM activity.
Results: The IPM extract at doses of 280 and 420 mg/kg BW and diclofenac inhibited paw oedema by 15.70 %, 15.94 % and 19.71 % respectively. IPM also reduced the incidence of arthritis and arthritic index. Unlike untreated rats, animals treated with IPM showed a significant decrease in the number of neutrophils and decreased expression of TNF-α and Interleukin-6. Histopathological examination showed a reduction in the number of inflammatory cells and hyperplasia of the synovium after IPM treatment.
Conclusion: This study showed that displays anti-rheumatoid arthritis activity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039107 | PMC |
| http://dx.doi.org/10.1016/j.jtcme.2021.07.006 | DOI Listing |
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