Decagram scale synthesis of favipiravir was performed in 9 steps using diethyl malonate as cheap starting material. Hydrogenation and bromination steps were achieved by employing a continuous flow reactor. The synthetic process provided a total of 16% yield and it is suitable for larger-scale synthesis and production.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044180 | PMC |
| http://dx.doi.org/10.1039/d1ra06963b | DOI Listing |
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