AI Article Synopsis

  • * This initiative encourages data-sharing and collaborative analysis to build strong evidence on the effectiveness and safety of treatments for these diseases.
  • * A Research Agenda has been developed to engage researchers and highlight important questions, with an emphasis on ethical data sharing as a means to help eliminate NTDs in the future.

Article Abstract

The Infectious Diseases Data Observatory (IDDO, https://www.iddo.org) has launched a clinical data platform for the collation, curation, standardisation and reuse of individual participant data (IPD) on treatments for two of the most globally important neglected tropical diseases (NTDs), schistosomiasis (SCH) and soil-transmitted helminthiases (STHs). This initiative aims to harness the power of data-sharing by facilitating collaborative joint analyses of pooled datasets to generate robust evidence on the efficacy and safety of anthelminthic treatment regimens. A crucial component of this endeavour has been the development of a Research Agenda to promote engagement with the SCH and STH research and disease control communities by highlighting key questions that could be tackled using data shared through the IDDO platform. Here, we give a contextual overview of the priority research themes articulated in the Research Agenda-a 'living' document hosted on the IDDO website-and describe the three-stage consultation process behind its development. We also discuss the sustainability and future directions of the platform, emphasising throughout the power and promise of ethical and equitable sharing and reuse of clinical data to support the elimination of NTDs.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020536PMC
http://dx.doi.org/10.12688/wellcomeopenres.17468.1DOI Listing

Publication Analysis

Top Keywords

soil-transmitted helminthiases
8
sharing reuse
8
reuse individual
8
individual participant
8
participant data
8
clinical data
8
data
6
improving anthelmintic
4
anthelmintic treatment
4
treatment schistosomiasis
4

Similar Publications

Background: Strongyloidiasis is a neglected tropical disease (NTD) caused by the soil-transmitted helminth Strongyloides stercoralis, recently included in the 2030 targets of the World Health Organization for the control of STHs. Assessment of infection prevalence is fundamental for decision-making about the implementation of control programs, but diagnostic assays to be applied in such context require evaluation. Seroassays based on recombinant antigens, which could be produced in a standardized and scalable manner, are particularly appealing for use in control programs.

View Article and Find Full Text PDF

Background/objectives: Despite efforts within the framework of the Sustainable Development Goal to end malnutrition by 2030, malnutrition and soil-transmitted helminth infections persist in sub-Saharan Africa. A significant barrier to success is the inadequate understanding of effective intervention methods. Most research on the gut microbiota's role in health has been conducted in developed countries, leaving a critical gap in knowledge regarding low-income populations.

View Article and Find Full Text PDF

Background: One of the most important pillars of action to achieve the elimination of trachoma and soil-transmitted helminth infections as a public health problem is the mass administration, at regular intervals, of azithromycin and anthielmintics, respectively, to a high proportion of the eligible population in endemic areas.

Objective: The objective of the study was to identify access barriers and facilitators for achieving coverage goals in the mass drugs administration, azithromycin and albendazole, in the department of Amazonas, Colombia.

Methodology: Implementation research was used, combining three types of qualitative research methodologies to collect information about access barriers and facilitators already described; These were individual and group interviews, focus group discussions and face-to-face intercultural dialogues.

View Article and Find Full Text PDF
Article Synopsis
  • * The study focused on the role of the complement anaphylatoxin C5a in hookworm infection during the early lung stage, revealing that C5aR1 mice had a reduced burden of hookworms and less lung damage compared to regular mice.
  • * Results showed that C5aR1 signaling in neutrophils plays a complex role in response to hookworm infections, highlighting an unexpected downside of complement activation in fighting parasites.
View Article and Find Full Text PDF
Article Synopsis
  • - The study assessed the prevalence of Schistosoma mansoni and soil-transmitted helminth infections among 363 schoolchildren in rural Ethiopia, finding an overall helminth infection rate of 59.8%, with significant instances of both single and multiple infections.
  • - Among those infected, 33.9% had S. mansoni and 38.8% had other soil-transmitted helminths, primarily Ascaris lumbricoides, Trichuris trichiura, hookworms, and Strongyloides stercoralis.
  • - Diagnostic methods used showed substantial agreement for detecting certain helminths, and the prevalence of S. mansoni was notably lower in children from Finchawa primary school compared
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!