AI Article Synopsis
- Upconversion nanoparticles (UCNPs) are advanced optical nanocrystals doped with lanthanide ions that show potential for improving tumor therapy by converting near-infrared (NIR) light into less harmful visible and ultraviolet (UV) radiation.
- Unlike traditional UV therapy, which can damage healthy tissue and has limited skin penetration, UCNPs can overcome these issues, making them a promising tool for treating various skin diseases.
- Current research on UCNPs is still in the early stages, but the paper reviews recent advances in their use for various treatment methods, including photodynamic therapy and immunotherapy, highlighting their potential for enhancing cancer treatment in the future.
Article Abstract
Upconversion nanoparticles (UCNPs) are a class of optical nanocrystals doped with lanthanide ions that offer great promise for applications in controllable tumor therapy. In recent years, UCNPs have become an important tool for studying the treatment of various malignant and nonmalignant cutaneous diseases. UCNPs convert near-infrared (NIR) radiation into shorter-wavelength visible and ultraviolet (UV) radiation, which is much better than conventional UV activated tumor therapy as strong UV-light can be damaging to healthy surrounding tissue. Moreover, UV light generally does not penetrate deeply into the skin, an issue that UCNPs can now address. However, the current studies are still in the early stage of research, with a long way to go before clinical implementation. In this paper, we systematically analysed recent advances in light-activated tumor therapy using functionalized UCNPs. We summarized the purpose and mechanism of UCNP-based photodynamic therapy (PDT), gene therapy, immunotherapy, chemo-therapy and integrated therapy. We believe the creation of functional materials based on UCNPs will offer superior performance and enable innovative applications, increasing the scope and opportunities for cancer therapy in the future.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043211 | PMC |
| http://dx.doi.org/10.1039/d1ra05638g | DOI Listing |
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