The introduction of an amino-group-terminated side chain into deep-red emissive benzo[,]indole-quinoline monomethine cyanine dye has led to the improved detection of RNAs as well as the imaging of nucleolar RNAs in cells.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042821PMC
http://dx.doi.org/10.1039/d1ra05872jDOI Listing

Publication Analysis

Top Keywords

side chain
8
deep-red fluorogenic
4
fluorogenic cyanine
4
cyanine dyes
4
dyes carrying
4
carrying amino
4
amino group-terminated
4
group-terminated side
4
chain improved
4
improved rna
4

Similar Publications

L-Threonine-Derived Biodegradable Polyurethane Nanoparticles for Sustained Carboplatin Release.

Pharmaceutics

December 2024

Department of Polymer Science and Engineering, Pusan National University, Busan 46241, Republic of Korea.

The use of polymeric nanoparticles (NPs) in drug delivery systems offers the advantages of enhancing drug efficacy and minimizing side effects; In this study, L-threonine polyurethane (LTPU) NPs have been fabricated by water-in-oil-in-water emulsion and solvent evaporation using biodegradable and biocompatible LTPU. This polymer was pre-synthesized through the use of an amino acid-based chain extender, desaminotyrosyl L-threonine hexyl ester (DLTHE), where urethane bonds are formed by poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) triblock copolymer and 1,6-hexamethylene diisocyanate (HDI). LTPU is designed to be degraded by hydrolysis and enzymatic activity due to the presence of ester bonds and peptide bonds within the polymer backbone.

View Article and Find Full Text PDF

Optically responsive materials are applied in sensing, actuators, and optical devices. One such class of material is dye-doped liquid crystal polymers that self-assemble into cholesteric mesophases that reflect visible light. We report here the synthesis and characterization of a family of linear and mildly crosslinked terpolymers prepared by the ROMP of norbornene-based monomers.

View Article and Find Full Text PDF

Radiation therapy (RT) is the cornerstone treatment for prostate cancer; however, it frequently induces gastrointestinal and genitourinary toxicities that substantially diminish the patients' quality of life. While many individuals experience transient side effects, a subset endures persistent, long-term complications. A promising strategy to mitigate these toxicities involves enhancing tumor radiosensitivity, potentially allowing for lower radiation doses.

View Article and Find Full Text PDF

Natural Cyclic Peptides: Synthetic Strategies and Biomedical Applications.

Biomedicines

January 2025

Department of Chemistry and Biochemistry, Augusta University, Augusta, GA 30912, USA.

Natural cyclic peptides, a diverse class of bioactive compounds, have been isolated from various natural sources and are renowned for their extensive structural variability and broad spectrum of medicinal properties. Over 40 cyclic peptides or their derivatives are currently approved as medicines, underscoring their significant therapeutic potential. These compounds are employed in diverse roles, including antibiotics, antifungals, antiparasitics, immune modulators, and anti-inflammatory agents.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!