Nitrileimines were implemented in practical click protocols with oxopropanenitriles for the straightforward 5-amino-1-pyrazole synthesis 1,3-dipolar cycloaddition. The reaction proceeds at room temperature in a short time with base catalysis and no chromatographic purification. High purity products were isolated by simple filtration. The selectivity of the reaction was observed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051556 | PMC |
| http://dx.doi.org/10.1039/d0ra01417f | DOI Listing |
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Nitrileimines as an alternative to azides in base-mediated click [3 + 2] cycloaddition with methylene active nitriles.
RSC Adv
April 2020
Department of Organic Chemistry, Ivan Franko National University of Lviv Kyryla i Mefodiya St. 6 Lviv 79005 Ukraine
Nitrileimines were implemented in practical click protocols with oxopropanenitriles for the straightforward 5-amino-1-pyrazole synthesis 1,3-dipolar cycloaddition. The reaction proceeds at room temperature in a short time with base catalysis and no chromatographic purification. High purity products were isolated by simple filtration.
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