Integration of high tumor-targeting capacity, controlling transport and low normal tissue retention into one engineered nanoparticle is a critical issue for future clinically translatable anti-cancer nanomedicines. Herein, hyaluronic acid functionalized 3.8 nm NaGdF nanodots (named NaGdF ND@HAs) have been prepared through conjugation of tryptone capped NaGdF nanodots (NaGdF ND@tryptone) with hyaluronic acid (HA, a naturally occurring glycosaminoglycan), which can recognize the overexpressed CD44 on cancer cell membranes. The as-prepared NaGdF ND@HAs have good paramagnetic properties (longitudinal relaxivity ( ) = 7.57 × 10 M S) and low cytotoxicity. The experimental results demonstrate that the NaGdF ND@HAs can not only efficiently accumulate in mouse-bearing MDA-MB-231 tumors ( 5.3% injection dosage (ID) g at 2 h post-injection), but also have an excellent renal clearance efficiency ( 75% injection dosage (ID) at 24 h post-injection). The as-prepared NaGdF ND@HAs have good paramagnetic properties with enhanced tumor-targeting capacity, which provides a useful strategy for the preparation of renal clearable magnetic resonance imaging (MRI) contrast agents for tumors.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051644 | PMC |
| http://dx.doi.org/10.1039/c9ra08974h | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Small upconversion-ruthenium nanohybrids for cancer theranostics.
Nanoscale
January 2025
McMaster University, Department of Engineering Physics, Hamilton, ON M8S 4K1, Canada.
Article Synopsis
- Photoresponsive drug delivery systems offer enhanced cancer treatment but face issues with size and limited light penetration.
- A new near infrared responsive system was created using azobenzene-modified silica nanoparticles that release a drug upon specific light excitation.
- The design allows for targeted delivery to cancer cell nuclei, facilitating DNA damage and cell destruction, making it a promising approach for effective cancer therapy.
Neuroinflammation-targeted magnetic resonance imaging nanoprobes for the early diagnosis of Alzheimer's disease.
J Mater Chem B
December 2024
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.
Alzheimer's disease (AD) that is an important contributor to dementia, is a chronic and irreversible neurodegenerative disease, with high rates of disability and mortality. Recently, more and more therapeutic methods have been developed to delay the progression of AD, but it remains a great challenge to achieve the early diagnosis of AD. In this work, we developed a magnetic resonance imaging (MRI) nanoprobe (NP@angiopep-2/CD137) based on angiopep-2 peptide and CD137 antibody with a NaGdF nanoparticle as the core and realized neuroinflammation-targeted imaging on APP/PS1 model mice using a clinical 7.
View Article and Find Full Text PDFThe application of upconversion nanomaterials relies heavily on the ability to produce bright upconversion luminescence (UCL) or high upconversion quantum yields (UCQYs) at low power density excitation. Herein, we synthesized silica-coated NaYF:Yb@NaGdF:Tm@NaYF:Tb upconversion nanoparticles (UCNPs) and CsPbI perovskites quantum dots (PeQDs) nanocomposites by the slow hydrolysis of (3-aminopropyl)triethoxysilane. The energy transfer (ET) of Gd→Tb accelerates the five-photon upconversion process of Yb-Tm and the design of the core@shell@shell layer effectively mitigates the energy jumps between Gd ions.
View Article and Find Full Text PDFTernary Heteronanocrystals with Dual-Heterojunction for Boosting Near-Infrared-Triggered Photo-Chemodynamic Therapy.
J Am Chem Soc
December 2024
Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, College of Chemistry and Materials, iChem (Collaborative Innovation Center of Chemistry for Energy Materials), Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, 200433 Shanghai, China.
Strongly coupled interfaces in the epitaxial growth heteronanocrystals (HNCs) provide advanced functionalities regarding interface connection, electron transfer, and carrier separation. However, the majority of current nanocomposites primarily focus on a single heterojunction involving only two subunits, which hinders the achievement of optimized synergy energy transfer among more than two components. Herein, ternary NaGdF:Yb,Tm-TiO:F-FeO HNCs with dual-heterojunction were synthesized based on the crystal plane epitaxial growth strategy for boosting near-infrared (NIR)-triggered photo-chemodynamic therapy (PCDT).
View Article and Find Full Text PDFDelayed Magnetic Resonance Imaging of Alzheimer's Disease by Using Poly(2-(methacryloyloxy)ethyl phosphorylcholine)-Functionalized Nanoprobes.
ACS Appl Mater Interfaces
December 2024
College of Materials Science and Engineering, and College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, commonly affecting the aged, with pathophysiological changes presenting 15 to 20 years before clinical symptoms. Early diagnosis and intervention are crucial in effectively slowing the progression of AD. In the current study, poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC)-functionalized NaGdF nanoparticles (NaGdF-PMPC) were developed as magnetic resonance imaging (MRI) contrast agents for targeting alpha 7 nicotinic acetylcholine receptors (α7 nAChRs) in AD mice.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!