An efficient eco-friendly catalyst-free three-component domino multicyclization for the synthesis of new spirobicyclic oxazolidinedione containing cyclopentenone moieties has been established by mixing amines, β-dicarbonyl compounds and ,'-dimethylalloxan in water at room temperature. This domino process involves multiple reactions such as enamination/aldol-like reaction/Stork enamine annulation/intramolecular cyclization under mild conditions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051567 | PMC |
| http://dx.doi.org/10.1039/d0ra01699c | DOI Listing |
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