An efficient and green strategy for the preparation of C3-difluoroarylmethylated quinoxalin-2(1)-one a visible-light-induced decarboxylative C3-difluoroarylmethylation of quinoxalin-2(1)-one with potassium 2,2-difluoro-2-arylacetate in water at room temperature was developed. This photoinduced reaction generated the desired products in good yields under simple and mild conditions.
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http://dx.doi.org/10.1039/d0ra02059a | DOI Listing |
J Org Chem
June 2020
College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou310014, P. R. China.
A facile Fe(III)-catalyzed oxidative decarboxylative radical coupling reaction of α,α-difluoroarylacetic acids with coumarins has been developed. This transformation, which provides a series of C-3 difluoroarylmethylated coumarins containing various functional groups in moderate-to-good yields, features easily accessible starting materials and operational simplicity.
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March 2020
Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, Department of Chemistry, Huaibei Normal University Huaibei Anhui 235000 P. R. China
An efficient and green strategy for the preparation of C3-difluoroarylmethylated quinoxalin-2(1)-one a visible-light-induced decarboxylative C3-difluoroarylmethylation of quinoxalin-2(1)-one with potassium 2,2-difluoro-2-arylacetate in water at room temperature was developed. This photoinduced reaction generated the desired products in good yields under simple and mild conditions.
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