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Photo-induced synthesis, structure and bioactivity of a natural cyclic peptide Yunnanin A analog. | LitMetric

Photo-induced synthesis, structure and bioactivity of a natural cyclic peptide Yunnanin A analog.

RSC Adv

Key Laboratory of Photochemistry Biomaterials and Energy Storage Materials of Heilongjiang Province, College of Chemistry & Chemical Engineering, Harbin Normal University Harbin 150025 China +86-451-88060569.

Published: December 2019

AI Article Synopsis

Article Abstract

A cyclic analog of natural peptide Yunnanin A was synthesized photoinduced single electron transfer reaction (SET) in the paper. The resulting compound exhibited potent bioactivity (with IC values 29.25 μg mL against HepG-2 cell lines and 65.01 μg mL against HeLa cell lines), but almost have no toxicity to normal cells (with IC values 203.25 μg mL against L929 cell lines), which may be served as a potential antitumor drug for medical treatment. The spatial structure was examined by experimental electronic circular dichroism (ECD) and quantum chemistry calculations. Moreover, the theoretical study suggested that special intramolecular hydrogen bonds and γ, β-turn secondary structures may be possible sources affecting cyclic peptide's bioactivity.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047273PMC
http://dx.doi.org/10.1039/c9ra09163gDOI Listing

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