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Remnant cholesterol and long-term incidence of death in coronary artery disease patients.
Atherosclerosis
November 2024
VIVIT-Institute, Academic Teaching Hospital Feldkirch, Feldkirch, Austria; Private University in the Principality of Liechtenstein, Triesen, Liechtenstein; Drexel University College of Medicine, Philadelphia, PA, USA.
Article Synopsis
- Remnant cholesterol (RC) has gained attention as a potential lipid factor for assessing cardiovascular risk, though previous data were often imprecise due to factors like non-fasting samples.
- In a study involving 1,474 CAD patients, researchers measured RC using strictly fasting samples and tracked all-cause and cardiovascular mortality, along with major adverse cardiovascular events (MACE), over an average follow-up of 11.6 years.
- The results indicated that higher RC levels were significantly associated with increased risks of all-cause mortality, cardiovascular mortality, and MACE, regardless of patient demographics or statin use, establishing RC as a reliable indicator of residual risk in CAD patients.
Oral Administration of a Novel, Synthetic Ketogenic Compound Elevates Blood β-Hydroxybutyrate Levels in Mice in Both Fasted and Fed Conditions.
Nutrients
October 2024
Laboratory of Metabolic Medicine, Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Article Synopsis
- Therapeutic nutritional ketosis, achieved through various dieting strategies, can help manage diseases like epilepsy, diabetes, and cancer, but sustaining it can be challenging.
- The study introduces a new synthetic triglyceride, glycerol tri-acetoacetate (Gly-3AcAc), which raises ketone levels in mice to a therapeutic range when administered.
- Results showed increased blood levels of β-hydroxybutyrate without harmful side effects, suggesting potential for this compound in enhancing methods to induce nutritional ketosis.
Associations between maternal per- and polyfluoroalkyl substances exposure and lipid levels in maternal and cord blood: The Japan environment and Children's study.
Environ Res
December 2024
Department of Preventive Medicine and Public Health, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan; Center for Perinatal, Pediatric, and Environmental Epidemiology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan; Department of Occupational Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.
Despite numerous studies, the associations between per- and polyfluoroalkyl substances (PFAS) exposure and various lipid levels in pregnant women remain ambiguous, especially concerning the association with cord blood lipids. This analysis included 20,960 pregnant women enrolled in the Japan Environment and Children's Study, recruited between 2011 and 2014. Non-fasting plasma samples collected before 22 weeks of gestation were examined for PFAS concentrations.
View Article and Find Full Text PDFAbdominal aorta intima-media thickness in children with hypothyroidism.
Pediatr Neonatol
September 2024
Pediatrics Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Hypothyroidism is associated with atherosclerosis, which is attributed mainly to an atherogenic lipid profile. Increased intima-media thickness (IMT) is the first structural change detected in atherosclerosis. This prospective cohort study investigated lipid profile and abdominal aorta IMT in patients newly-diagnosed with hypothyroidism and their change one year post-treatment.
View Article and Find Full Text PDFSerum concentrations of lipids, ketones and acylcarnitines during the postprandial and fasting state: the Postprandial Metabolism (PoMet) study in healthy young adults.
Br J Nutr
October 2024
Mohn Nutrition Research Laboratory, Centre for Nutrition, Department of Clinical Science, University of Bergen, Bergen, Norway.
To improve the interpretation and utilisation of blood lipids, ketones and acylcarnitine concentrations as biomarkers in clinical assessments, more information is needed on their dynamic alterations in response to dietary intake and fasting. The aim of this intervention study was to characterise the changes in serum lipid, ketone and acylcarnitine concentrations 24 h after a standardised breakfast meal. Thirty-four healthy subjects (eighteen males and sixteen females) aged 20-30 years were served a breakfast meal (∼500 kcal, 36 E% fat, 46 E% carbohydrates, 16 E% protein, 2E% fibre), after which they consumed only water for 24 h.
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