We performed a pilot study to assess the immunogenicity and safety of intradermal hepatitis B (HB) virus vaccines in people living with HIV (PLWH). This single-center prospective study was conducted in Yokohama, Japan. Adult PLWH with serum antibodies against HB surface antigen (anti-HBs) <10 mIU/mL at all time points after standard HB vaccination were included. We administered HB surface antigen (total dose of 10 μg) at 5 separate sites intradermally at baseline, one month, and 6-9 months and measured anti-HBs 1-3 months after administration. Eleven PLWH were included in this study. The mean age was 36 years, and all patients were men. At baseline, all patients were on antiretroviral therapy, and the mean CD4+ lymphocyte count was 588 /μL and plasma HIV-RNA was <20 copies/mL, except for one patient. Anti-HB levels were elevated to >10 mIU/mL in one patient after one dose, 6 patients after 2 doses, and 4 patients after 3 doses of the intradermal vaccines. Eight patients experienced grade 1 local adverse events. Additional vaccination via the intradermal route induced an anti-HBs level >10 mIU/mL in all patients, without serious adverse events.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.7883/yoken.JJID.2021.834 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Liposome-loaded dissolvable microneedle patches for more efficient intradermal antigen delivery of Hepatitis B vaccine.
Int J Pharm
January 2025
Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai 201203, China. Electronic address:
The aim of this study was to improve the efficacy of Hepatitis B surface antigen (HBsAg) vaccination via liposome-loaded dissolvable microneedle (Lipo-dMN) patches. HBsAg liposomes were prepared using the thin-film hydration method and subsequently incorporated into dissolvable microneedle patches via a pre-vacuum approach. Liposomes, dissolvable microneedle patches (dMN), and Lipo-dMN were characterized for encapsulation efficiency, mechanical properties, morphology, skin insertion, in vitro release, cellular uptake, and in vivo vaccination studies.
View Article and Find Full Text PDFExperimental infection of ringtail possums (Pseudocheirus peregrinus) with Mycobacterium ulcerans, the agent of Buruli ulcer.
Sci Rep
October 2024
Department of Infectious Diseases, Barwon Health, Geelong, VIC, Australia.
Article Synopsis
- Buruli ulcer (BU) is a skin disease caused by the bacterium Mycobacterium ulcerans, which is increasingly seen in Australia where possums serve as a reservoir for the infection.
- In a study, six wild-caught possums that had never been exposed to MU were injected and all developed BU, with ulceration occurring between 49 and 77 days after infection.
- The findings revealed systemic infection signs in most possums, indicating that this model can enhance understanding of how the bacterium spreads and can inform strategies to prevent further transmission and outbreaks.
Overview of Hepatitis B Vaccine Non-Response and Associated B Cell Amnesia: A Scoping Review.
Pathogens
July 2024
Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto 840232, Nigeria.
Background: The advent of the hepatitis B vaccine has achieved tremendous success in eradicating and reducing the burden of hepatitis B infection, which is the main culprit for hepatocellular carcinoma-one of the most fatal malignancies globally. Response to the vaccine is achieved in about 90-95% of healthy individuals and up to only 50% in immunocompromised patients. This review aimed to provide an overview of hepatitis B vaccine non-response, the mechanisms involved, B cell amnesia, and strategies to overcome it.
View Article and Find Full Text PDFNeonatal BCG Vaccination for Prevention of Allergy in Infants: The MIS BAIR Randomised Controlled Trial.
Clin Exp Allergy
September 2024
Infectious Diseases, Clinical Epidemiology & Biostatistics Unit, Population Allergy, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Background: The beneficial off-target effects of Bacille Calmette-Guérin (BCG) vaccination potentially include protection against allergy.
Objective: In the MIS BAIR trial, we aimed to determine whether neonatal BCG vaccination reduces atopic sensitisation and clinical food allergy in infants.
Methods: In this randomised controlled trial, 1272 neonates were allocated to BCG-Denmark vaccine (0.
Investigation of an Mpox Outbreak Affecting Many Vaccinated Persons in Chicago, Illinois-March 2023-June 2023.
Clin Infect Dis
July 2024
Chicago Department of Public Health, Chicago, Illinois, USA.
Article Synopsis
- In May 2023, an increase in mpox cases was observed in Chicago, primarily among fully vaccinated individuals, prompting an investigation into the outbreak's characteristics and causes.
- Researchers assessed demographic and health data from patients, analyzed viral genomes, and evaluated the humoral antibody responses to understand vaccine effectiveness and potential compromises.
- Of the 49 identified cases, 57% were fully vaccinated, with findings suggesting that increased exposure through higher median numbers of sexual partners was a key factor in the outbreak, despite overall vaccine effectiveness.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!