AI Article Synopsis
- Researchers discovered three new sulfated naphthopyrone derivatives (delicapyrons F-H) and two new sulfated anthraquinone derivatives (delicaquinons A and B) from the Vietnamese crinoid Comanthus delicata.
- The chemical structures of these compounds were determined using advanced techniques, including 1D and 2D-NMR and high-resolution mass spectrometry.
- Among these compounds, 6 showed strong cytotoxic effects against prostate cancer cells, while the other compounds exhibited varying levels of cytotoxicity against melanoma and prostate cancer cell lines.
Article Abstract
Three new sulfated naphthopyrone derivatives namely delicapyrons F-H (1-3) and two new sulfated anthraquinone derivatives namely delicaquinons A (4) and B (5), together with 6-methoxycomaparvin-5-methylether-8-O-sodium sulfate (6), 6-methoxycomaparvin-8-O-sodium sulfate (7), comaparvin-8-O-sodium sulfate (8), and 3-propyl-1,6,8-trihydroxy-9,10-anthraquinone-6-O-sodium sulfate (9) were isolated from the Vietnamese crinoid Comanthus delicata. Their chemical structures were elucidated by extensive analysis of the one dimensional (1D) and 2D-NMR, high resolution electrospray ionization quadrupole time-of-flight (HR-ESI-QTOF) mass spectra as well as calculation of optical rotation. In addition, significant cytotoxicity was observed for 6 against LNCaP (prostate cancer) cell line with IC value of 20.29 ± 2.43 µM, whereas moderate or weak cytotoxic effects were observed for 1-3 and 5-8 on SK-Mel-2 (melanoma) cell line and 7 and 8 against LNCaP cell line, with IC values ranging from 49.96 ± 1.74 to 76.92 ± 5.85 µM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1248/cpb.c21-00904 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!