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Elevated plasma total homocysteine levels are associated with behavioral and psychological symptoms in dementia with Lewy bodies.
Front Neurosci
November 2024
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- This study aimed to explore the link between plasma total homocysteine (tHcy) levels and behavioral and psychological symptoms of dementia (BPSD) in patients with dementia with Lewy bodies (DLB).
- Among 82 DLB patients, a significant 92.7% exhibited clinically significant BPSD, with hallucinations and apathy being the most common symptoms; elevated tHcy levels were notably associated with higher NPI scores in DLB patients.
- The findings suggest that controlling homocysteine levels might provide a new approach for managing BPSD in DLB, although further research with larger groups is needed to confirm these results.
Contrast-induced encephalopathy with visual and auditory hallucinations triggered by coronary angiography with iodixanol: a case report.
Egypt Heart J
December 2024
Department of Interventional Cardiology and Internal Diseases, Military Institute of Medicine - National Research Institute, Zegrzyńska 8 Street, 05-119, Legionowo, Poland.
Article Synopsis
- Contrast-induced encephalopathy (CIE) is a rare but serious complication after coronary angiography, often presenting as transient cortical blindness; however, this case reports the first instance of CIE accompanied by visual and auditory hallucinations.
- An 80-year-old female patient experienced confusion and hallucinations following an elective coronary procedure, after complications were encountered during the angiography; stroke was initially suspected but ruled out through MRI.
- The patient was diagnosed with CIE and treated with sedation and quetiapine for her hallucinations, ultimately leading to the resolution of her symptoms within five days.
Clinical Predictors of Mortality in People with Severe Behavioral and Psychological Symptoms of Dementia.
J Am Med Dir Assoc
November 2024
FERB Alzheimer Centre, Gazzaniga, Italy.
Article Synopsis
- Dementia, particularly with severe behavioral and psychological symptoms (BPSD), greatly affects quality of life and is a main cause of death in older adults; this study looked at factors predicting mortality in these patients.
- Over 4 years, 32.5% of 508 participants with severe BPSD died, with non-survivors generally being older, more likely male, and showing greater symptom severity and lower cognitive and functional capabilities at the start.
- Key mortality predictors identified were male sex, older age at diagnosis, higher BPSD severity scores, lower cognitive function, worse daily living capabilities, and lower quality of life, while the use of antidepressants was linked to a reduced mortality risk.
Frailty and Behavioral and Psychological Symptoms of Dementia: A Single Center Study.
Geriatrics (Basel)
November 2024
Geriatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56124 Pisa, Italy.
During the time-course of cognitive decline, Behavioral and Psychological Symptoms of Dementia (BPSD) may arise, negatively impacting the outcomes. The aim of this single center, longitudinal study was to evaluate the correlation between frailty and BPSD in a population of older patients with dementia. BPSD were classified into three clusters: "mood/apathy" (depression, apathy, sleep disturbances, appetite disturbances), "psychosis" (delusions, hallucinations, and anxiety), and "hyperactivity" (agitation, elation, motor aberrant behavior, irritability, disinhibition).
View Article and Find Full Text PDFAnti-NMDA receptor autoimmune encephalitis associated with ovarian teratoma: A case series and literature review.
Int J Gynaecol Obstet
November 2024
Women's Health Center, Vinmec Times City Hospital, Hanoi, Vietnam.
Autoimmune encephalitis is a group of disorders characterized by symptoms of dysfunction of the limbic and extra-limbic systems that occur in association with antibodies against intracellular antigens, synapses, or proteins located on the surface of nerve cells. Anti-NMDA (N-methyl-D-aspartate) receptor encephalitis was first described in 2007 and has become one of the most commonly recognized autoimmune encephalitides. The disease is predominantly female (81%) and affects young patients (37% <18 years old, 95% <45 years old), with up to 58% of women over 18 years old having ovarian teratoma.
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