The number of patients presenting with cirrhosis with kidney injury and the potential need for SLKT is increasing. In 2017, standardized criteria were implemented to identify candidates for SLKT as well as criteria for prioritizing LTA recipients for kidney transplant if they developed kidney failure, which is referred to as the 'safety net rule.' Goal of the safety net rule is to provide a pathway that provides increased priority to LTA recipients with renal failure who may have previously undergone SLKT. This article reviews the pros and cons of the safety net rule for liver transplant recipients who develop ESRD.
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http://dx.doi.org/10.1016/j.cld.2022.01.005 | DOI Listing |
Eur J Clin Pharmacol
December 2024
Center for Pharmacometrics, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, No.1200 Cailun Road, Shanghai, 201203, China.
Objectives: This study aimed to quantitatively evaluate the efficacy and safety of first-line systemic therapies for treating advanced hepatocellular carcinoma (aHCC).
Methods: The study included clinical trials of first-line systemic therapies for aHCC since the approval of sorafenib in 2007. Hazard function models were used to describe changes in overall survival (OS) and progression-free survival (PFS) over time.
Mar Drugs
December 2024
Centre for Environment Fisheries and Aquaculture Science (CEFAS), Barrack Road, Weymouth DT4 8UB, UK.
Harmful algal biotoxins in the marine environment are a threat to human food safety due to their bioaccumulation in bivalve shellfish. Whilst official control monitoring provides ongoing risk management for regulated toxins in live bivalve molluscs, no routine monitoring system is currently in operation in the UK for other non-regulated toxins. To assess the potential presence of such compounds, a systematic screen of bivalve shellfish was conducted throughout Great Britain.
View Article and Find Full Text PDFJ Public Health Manag Pract
December 2024
Office of Ambulatory Care and Population Health, New York City Health + Hospitals, New York, New York (Newton-Dame, Jacobson and Silverman); Office of Ambulatory Care and Population Health, New York City Health + Hospitals, NYU Grossman School of Medicine, New York, New York (Drs Wallach and Long); and Department of Pediatrics, New York City Health + Hospitals/Bellevue, NYU Grossman School of Medicine, New York, New York (Dr Dreyer).
Context: Over 200 000 people seeking asylum have arrived in New York City from 2022 to 2024.
Program: As the safety net hospital system for our city, New York City (NYC) Health + Hospitals (H + H) has taken the lead in caring for newly arrived asylum seekers. We used electronic medical record data to gain early insights into utilization and needs among these patients.
Lancet Digit Health
January 2025
Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Harvard Medical School, Boston, MA, USA. Electronic address:
Background: Palliative spine radiation therapy is prone to treatment at the wrong anatomic level. We developed a fully automated deep learning-based spine-targeting quality assurance system (DL-SpiQA) for detecting treatment at the wrong anatomic level. DL-SpiQA was evaluated based on retrospective testing of spine radiation therapy treatments and prospective clinical deployment.
View Article and Find Full Text PDFSci Total Environ
December 2024
China Academy of Safety Science and Technology, No. 32 Beiyuan Road, Beijing 100012, China.
China's energy mix is coal-dominated; therefore, it is unrealistic for the country to achieve carbon neutrality through complete decarbonization. As the world's largest carbon emitter, achieving global carbon reduction targets necessitates that China develops low-carbon, clean, safe, and efficient coal development and utilization technologies. This study proposes a new low-carbon coal development and utilization method that integrates in-situ conversion mining and mineral carbonation (ICMMC) to realize coal mining and separation, in-situ backfilling, in-situ conversion, energy storage, and carbon sequestration.
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