AI Article Synopsis
- Pulmonary infections from mycobacteria significantly impact human health, leading to high rates of illness and death, with diagnosis often taking a long time.
- Prior research indicated that analyzing volatile molecules in exhaled breath might help detect these infections more quickly.
- This study identified 17 specific volatile molecules in the breath of cystic fibrosis patients that can differentiate between those with active mycobacterial disease, those with indolent infections, and those who have never been infected, highlighting the need for further research on these biomarkers as a non-invasive diagnostic tool.
Article Abstract
Pulmonary infections caused by mycobacteria cause significant mortality and morbidity in the human population. Diagnosing mycobacterial infections is challenging. An infection can lead to active disease or remain indolent with little clinical consequence. In patients with pulmonary(PNTM) identification of infection and diagnosis of disease can take months to years. Our previous studies showed the potential diagnostic power of volatile molecules in the exhaled breath samples to detect active pulmonaryinfection. Herein, we demonstrate the ability to detect the disease status of PNTM in the breath of persons with cystic fibrosis (PwCF). We putatively identified 17 volatile molecules that could discriminate between active-NTM disease (= 6), indolent patients (= 3), and those patients who have never cultured an NTM (= 2). The results suggest that further confirmation of the breath biomarkers as a non-invasive and culture-independent tool for diagnosis of NTM disease in a larger cohort of PwCF is warranted.
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| http://dx.doi.org/10.1088/1752-7163/ac6bb6 | DOI Listing |
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