AI Article Synopsis
- - Chagas Disease, caused by the Trypanosoma cruzi parasite, affects around seven million people globally and has limited treatment options.
- - A study tested essential oils from 18 Myrtaceae plant species for their effectiveness against T. cruzi and identified eight oils with strong anti-parasitic properties (IC <10 μg/mL, SI >10).
- - Key compounds such as (E)-caryophyllene and α-humulene were found to significantly contribute to the oils' ability to combat the parasite, highlighting the potential of these essential oils as sources of bioactive compounds.
Article Abstract
Chagas Disease (CD), caused by flagellate protozoan Trypanosoma cruzi, is a Neglected Tropical Diseases (NTD) that affect approximately seven million people worldwide with a restrict therapeutical arsenal. In the present study, the essential oils from 18 Myrtaceae species were extracted, chemically dereplicated, and evaluated in vitro against T. cruzi. From these, eight essential oils were considered promising (IC <10 μg/mL and SI>10) against the protozoan: Eugenia florida, E. acutata, E. widgrenii, Calyptranthes brasilienses, C. widgreniana, Plinia cauliflora, Campomanesia xanthocarpa, and Psidium guajava. Multivariate data analysis pointed out (E)-caryophyllene, α-humulene, limonene, caryophyllene oxide, and α-copaene playing an important role in the anti-T. cruzi activity. The obtained results demonstrated the potential of essential oils of Myrtaceae species as valuable sources of bioactive compounds against T. cruzi.
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| http://dx.doi.org/10.1002/cbdv.202200198 | DOI Listing |
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