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Factors influencing negative outcomes for nurses who experience patient safety incidents: An integrative review.
Int Nurs Rev
March 2025
College of Nursing, Seoul, National University, Seoul, South Korea.
Aim: To synthesize evidence on factors influencing negative outcomes following patient safety incidents.
Background: Patient safety incidents affect not only patients and families but also healthcare workers (second victims) and institutions (third victims). Nurses are at risk due to stressful environments and direct patient care, leading to defensive practices, job turnover, and errors.
Empiric antibiotic therapy resistance and mortality in emergency department patients with bloodstream infection: a retrospective cohort study.
BMC Emerg Med
January 2025
Department of Emergency Medicine, Semmelweis University, Ulloi ut 78/A, Budapest, 1082, Hungary.
Background: Timely management of sepsis in the emergency department, including the use of appropriate antimicrobials, is crucial for improving patient outcomes. Inadequate empiric antimicrobial treatment is associated with potential changes in patient outcomes. We aimed to pinpoint risk factors, characterize antibiotic resistance trends, and investigate the association between antibiotic resistance and mortality among patients with bacteremia admitted to the emergency department.
View Article and Find Full Text PDFFitness, Body Composition, and Health Behaviors in Long-Term Survivors of Adolescent and Young Adult Cancers.
J Adolesc Young Adult Oncol
January 2025
Deakin University, Institute for Physical Activity and Nutrition (IPAN), Geelong, Australia.
To investigate cardiorespiratory fitness (CRF), body composition, health behaviors, and health-related quality of life (HRQoL) in adolescent and young adult cancer survivors (AYA-CS) compared with age-matched counterparts without a cancer diagnosis. This cross-sectional study recruited participants aged 15-25 years at the time of their cancer diagnosis and ≥ 5 years post-treatment. Participants completed cardiopulmonary exercise testing, dual-energy X-ray absorptiometry, food diaries, physical activity (PA), fatigue, and HRQoL questionnaires.
View Article and Find Full Text PDFStatoliths function in gravity perception in plants: yes, no, yes!
Planta
January 2025
Department of Biomedical Engineering and Science, Florida Institute of Technology, Melbourne, FL, 32901, USA.
The starch-statolith theory was established science for a century when the existence of gravitropic, starchless mutants questioned its premise. However, detailed kinetic studies support a statolith-based mechanism for graviperception. Gravitropism is the directed growth of plants in response to gravity, and the starch-statolith hypothesis has had a consensus among scientists as the accepted model for gravity perception.
View Article and Find Full Text PDFFDA-approved drugs featuring macrocycles or medium-sized rings.
Arch Pharm (Weinheim)
January 2025
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing, China.
Macrocycles or medium-sized rings offer diverse functionality and stereochemical complexity in a well-organized ring structure, allowing them to fulfill various biochemical functions, resulting in high affinity and selectivity for protein targets, while preserving sufficient bioavailability to reach intracellular compartments. These features have made macrocycles attractive candidates in organic synthesis and drug discovery. Since the 20th century, more than three-score macrocyclic drugs, including radiopharmaceuticals, have been approved by the US Food and Drug Administration (FDA) for treating bacterial and viral infections, cancer, obesity, immunosuppression, inflammatory, and neurological disorders, managing cardiovascular diseases, diabetes, and more.
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