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http://dx.doi.org/10.1111/jocs.16560 | DOI Listing |
World J Urol
January 2025
Department of Urology, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing, China.
J Mol Model
January 2025
Laboratorio de Química Teórica Computacional (QTC), Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Avenida Vicuña Mackenna 4860, 7820436, Santiago de Chile, Chile.
Context: Dopamine -monooxygenase (D M) is an essential enzyme in the organism that regioselectively converts dopamine into R-norepinephrine, the key step of the reaction, studied in this paper, is a hydrogen atom transfer (HAT) from dopamine to a superoxo complex on D M, forming a hydroperoxo intermediate and dopamine radical. It was found that the formation of a hydrogen bond between dopamine and the D M catalyst strengthens the substrate-enzyme interaction and facilitates the HAT which takes place selectively to give the desired enantiomeric form of the product. Six reactions leading to the hydroperoxo intermediate were analyzed in detail using theoretical and computational tools in order to identify the most probable reaction mechanism.
View Article and Find Full Text PDFJ Hypertens
February 2025
Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, Texas, USA.
Tunis Med
December 2024
Université de Sousse, Faculté de Médecine de Sousse, Hôpital Farhat Hached, Laboratoire de recherche LR12SP09 « Insuffisance cardiaque », 4000 Sousse, Tunisie.
Introduction: The cover letter is a critical component of medical journal submissions, often influencing acceptance decisions. However, authors frequently underestimate its importance. This narrative review aimed to provide guidance for authors on writing effective and succinct cover letters.
View Article and Find Full Text PDFGlobal Spine J
January 2025
Department of orthopaedics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
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