In this work, we describe the preparation of double-decker cage [1-H] comprising two binding pockets, each with three ammonium and three amide hydrogen bonding sites. This novel host possesses a high affinity for trapping two molecules of ATP in an allosteric fashion, with both experiments and theory suggesting the synergistic action of charged hydrogen bonds and π-π stacking in the encapsulation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d2cc00927g | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Conjugation through Si-O-Si bonds, silsesquioxane (SQ) half cage copolymers, extended examples SiO/SiO units: multiple emissive states in violation of Kasha's rule.
Dalton Trans
June 2024
Department of Mater. Sci. and Engin., Macromolecular Science and Eng. Center University of Michigan, Ann Arbor, 48109-21236, USA.
We previously reported that phenyl- and vinyl-silsesquioxanes (SQs), [RSiO] (R = Ph or vinyl) functionalized with three or more conjugated moieties show red-shifted absorption- and emission features suggesting 3-D conjugation a cage centered LUMOs. Corner missing [PhSiO](OSiMe) and edge opened, end capped [PhSiO](OSiMe) (double decker, DD) analogs also offer red shifted spectra again indicating 3-D conjugation and a cage centered LUMO. Copolymerization of DD [PhSiO](OSiMevinyl) with multiple R-Ar-Br gives copolymers with emission red-shifts that change with degree of polymerization (DP), exhibit charge transfer to FTNCQ and terpolymer averaged red-shifts suggesting through chain conjugation even with two (O-Si-O) end caps possibly a cage centered LUMO.
View Article and Find Full Text PDFDouble-decker cage reduces mount frequency and ejaculation latency, resulting in reduced weight loss in male rats after mating behavior.
Exp Anim
October 2024
Laboratory Animal Center, Institute for Promotion of Medical Science Research, Yamagata University Faculty of Medicine, 2-2-2 Iidanishi, Yamagata 990-9585, Japan.
Rats were the first mammals to be domesticated for scientific research, and abundant physiological data are available on them. Rats are expected to continue to play an important role as experimental animals, especially with advancements such as CRISPR/Cas9 technology. Environmental enrichment aims to promote species-specific behaviors and psychological well-being.
View Article and Find Full Text PDFHigh-Thermal Stable Epoxy Resin through Blending Nanoarchitectonics with Double-Decker-Shaped Polyhedral Silsesquioxane-Functionalized Benzoxazine Derivatives.
Polymers (Basel)
December 2023
Department of Materials and Optoelectronic Science, Center for Functional Polymers and Supramolecular Materials, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.
A series of di-functional benzoxazine (BZ) monomers was synthesized, specifically the double-decker silsesquioxane (DDSQ) cage structure (DDSQ-BZ). Comparative analyses were conducted between DDSQ-BZ monomers and the most commonly utilized bisphenol A-functionalized bifunctional benzoxazine (BPA-BZ) monomer. DDSQ-BZ compounds possess better thermal properties such as high char yield and high thermal decomposition temperature () after thermal ring-opening polymerization (ROP) because the inorganic DDSQ cage nanostructure features a nano-reinforcement effect.
View Article and Find Full Text PDFUnprecedented Route to Amide-Functionalized Double-Decker Silsesquioxanes Using Carboxylic Acid Derivatives and a Hydrochloride Salt of Aminopropyl-DDSQ.
Inorg Chem
April 2023
Faculty of Chemistry, University of Wrocław, 14 F. Joliot-Curie, 50-383 Wrocław, Poland.
An easy, efficient, and scalable synthetic procedure is described to obtain novel amide-functionalized double-decker silsesquioxanes (DDSQs). The use of mild conditions of deprotection of the BOC group, which does not result to the cleavage of the cage-like silsesquioxane structure, is reported. This method leads to the so far undescribed hydrochloride salt of aminoalkyl-DDSQ.
View Article and Find Full Text PDFA Brief Review on Selected Applications of Hybrid Materials Based on Functionalized Cage-like Silsesquioxanes.
Polymers (Basel)
March 2023
Faculty of Chemistry, University of Wrocław, 14 F. Joliot-Curie, 50-383 Wrocław, Poland.
Rapid developments in materials engineering are accompanied by the equally rapid development of new technologies, which are now increasingly used in various branches of our life. The current research trend concerns the development of methods for obtaining new materials engineering systems and searching for relationships between the structure and physicochemical properties. A recent increase in the demand for well-defined and thermally stable systems has highlighted the importance of polyhedral oligomeric silsesquioxane (POSS) and double-decker silsesquioxane (DDSQ) architectures.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!