AI Article Synopsis
- The study aimed to explore the connections between preterm birth, small-for-gestational age (SGA), preeclampsia, and placental abruption with the development of ADHD in children.
- The research followed over 1.2 million children in Sweden born between 2002 and 2014, examining ADHD diagnoses from ages 3 to 15 and using various statistical analyses to assess risk factors.
- Findings revealed a significant increase in ADHD diagnoses associated with preterm births and SGA, with specific gestational age impacts highlighted, while preeclampsia also linked to a higher incidence of ADHD.
Article Abstract
Aim: The aim of this study was to investigate preterm birth, small-for-gestational age (SGA), preeclampsia and placental abruption in relation to attention-deficit/hyperactivity disorder (ADHD) in offspring.
Methods: We conducted a population-based cohort study among non-malformed live-born singleton children in Sweden born during 2002-2014. Using national registries with recorded information, we followed 1,212,201 children for an ADHD diagnosis from 3 to 15 years. We compared ADHD rates between exposure categories using adjusted hazard ratios (HR) with 95% confidence intervals (CI) from Cox proportional hazards models. We also conducted sibling-controlled analyses among 751,464 full siblings.
Results: There were 27,665 ADHD diagnoses in the cohort. Compared with term birth (≥37 weeks), adjusted HR (95% CI) for ADHD increased with decreasing gestational age: 1.18 (1.11, 1.25), 1.61 (1.37, 1.89) and 2.79 (2.23, 3.49) for 32-36 weeks, 28-31 weeks and 22-27 weeks. Both spontaneous and medically indicated preterm birth were associated with ADHD. SGA was related to 1.62 (1.49, 1.77) times higher ADHD incidence. Preeclampsia, but not placental abruption, was associated with ADHD. Sibling-controlled analyses showed similar results. Preterm birth did not fully explain the associations of SGA or preeclampsia with ADHD.
Conclusion: Preterm birth, SGA and preeclampsia are related to ADHD incidence in offspring.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544732 | PMC |
| http://dx.doi.org/10.1111/apa.16375 | DOI Listing |
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