In this study, a green, low-cost strategy is reported for the synthesis of carbon dots (CDs) using L. A systematic metabolic analysis and determination of the biodistribution of the nitrogen-doped carbon dots was conducted in mice. Fluorescence images of carbon dots in the whole body, in individual organs (kidney, gallbladder, and bladder), and in two cell lines from different tissue sources were observed. The results suggest not only that the carbon dots are fluorescent in solution, as reported previously, but also that they behave well as contrast agents in live mice. Moreover, metabolic process curves of carbon dots in blood and urine were obtained for the first time. Unlike quantum dots, which can persist in the body for more than 7 days, the carbon dots diffused and were excreted very quickly after injection into mice; within 3 min, fluorescence could be observed in blood, tissue and urine, indicating the rapid distribution of CDs. The fluorescence faded by approximately 4 h in organs and by approximately 10 h in urine, indicating that the CDs were excreted completely in half a day. Our results on the absorption, distribution, metabolism, and excretion of carbon dots may have great significance for the application of these CDs in drug delivery, as drug targets, and for biological imaging. We also demonstrated that these CDs have good biocompatibility for use in studies of mother-child barriers and in fluorescence imaging in plants.
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http://dx.doi.org/10.1166/jbn.2022.3245 | DOI Listing |
BMC Cancer
January 2025
Taras Shevchenko National University of Kyiv, 64/13, Volodymyrska Street, Kyiv, 01601, Ukraine.
Background: nowadays, the photoacoustic imaging is in the mainstream of cancer theranostics. In this study the nanoparticles with previously proven photoacoustic imaging properties, i.e.
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January 2025
Department of Chemistry, Amrita School of Physical Sciences Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, India.
Carbon dots doped with metals and non-metals have gained much popularity due to the enhancement in their optical and electronic properties. In this study, polyethyleneimine-functionalized transition metal (nickel or copper) doped carbon dots (CD, NiCD and CuCD) were synthesized through hydrothermal method. The carbon dots exhibited a blue fluorescence at 470 nm when excited at 350 nm.
View Article and Find Full Text PDFCarbohydr Polym
March 2025
College of Chemistry, Zhengzhou University, Zhengzhou 450000, China. Electronic address:
Soft actuators for intelligent robots require further elaboration to improve their biomedical applicability, which has led to the development of a series of flexible stimulus-responsive materials. However, fabricating degradable soft actuators that exhibit synergistic color and shape changes in response to environmental stimuli remains challenging. Here, we developed a soft actuating gel based on carbon dots (CDs) that are chemically cross-linked with sodium alginate.
View Article and Find Full Text PDFCarbohydr Polym
March 2025
School of Environmental and Architecture, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address:
Carbon dots (CDs) mediated g-CN (CN) is a promising visible-light-driven semiconductor in catalyzing peroxymonosulfate (PMS) for aqueous contaminants remediation. However, the poor dispersibility of powered catalyst and its challenging recyclability impede their broader application. Herein, we embedded FeN bridge within the g-CN framework and immobilized g-CN gel beads (CA/FNCCN) through a 3D cross-linking process with sodium alginate.
View Article and Find Full Text PDFChemSusChem
January 2025
Griffith University, School of Engineering and Built Environment, 170 Kessels Rd, 4111, Nathan, AUSTRALIA.
Carbon dots (CDs) as a new class of photoluminescent zero-dimension carbon nanoparticles have attracted significant research interests owing to their extraordinary opto-electro-properties and biocompatibility. So far, almost all syntheses of CDs require either heat treatment or exertion of high energy fields. Herein, a scalable room-temperature vortex fluidic method is introduced to the CDs synthesis using the angled vortex fluidic device (VFD).
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