The oxygen level is key benthic ecosystem health. In this study, a new kind of slow-release oxygen material (SROM) was developed and evaluated in a simulation experiment. The effects of SROM dose and dosing method on the pH and DO, the release of nitrogen and phosphorus, and greenhouse gas emissions were studied. The restoration of typical benthic species (Ceratophyllum represented submerged plants and Cipangopaludina cahayensis represented benthic animals) was also evaluated based on the analysis of catalase and peroxidase activities, survival rate, and biomass. The result shows that dosing SROM on mud surfaces had a better effect than dosing in mud. When dosing SROM on the surface of mud at a suitable dose, the DO of water increased from 0.5 mg/L to higher than 4 mg/L, and the pH was below 9, which would be suitable for the survival of benthos. Dosing SROM could also cause the concentrations of nutrient elements (NH-N, TN, TP, and PO) in overlying water and the emission flux of CH and CO to decrease. In addition, the growth of Ceratophyllum and Cipangopaludina cahayensis was accelerated, which benefited the restoration of benthic ecosystems. For microbial community structure, various of bacteria for nitrogen and the phosphorus cycle were found in the sediment (including aerobic denitrifying bacteria). Dosing SROM could increase the Simpson index of the bacterial community, means an increase in bacterial diversity. The results show that the dosing of SROM could be an effective method in the early stage of benthic habitat restoration.
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http://dx.doi.org/10.1016/j.chemosphere.2022.134658 | DOI Listing |
Addiction
August 2024
Centre for Advancing Health Outcomes, Vancouver, British Columbia, Canada.
Background And Aim: In British Columbia, Canada, clinical guidelines for the treatment of opioid use disorders (OUD) were updated in 2017, during a period in which the potency and composition of the illicit drug supply changed rapidly. We aimed to describe changes in opioid agonist treatment (OAT) prescribing practices at the population level in a setting in which fentanyl and its analogs have become the primary illicit opioid of use.
Design, Setting And Participants: This was a population-based retrospective cohort study using three linked health administrative databases in British Columbia (BC), Canada.
Eur J Med Res
December 2023
Department of Family & Community Medicine, University of Toronto, Toronto, Canada.
Background: Methadone titration in an outpatient setting typically involves initiation with subtherapeutic doses with slow titration to mitigate the risks of respiratory depression and overdose. In pregnancy, and generally, subtherapeutic doses of methadone and slow titrations are associated with poorer outcomes in terms of treatment retention and ongoing illicit opioid use. We aim to describe rapid titration of OAT in an inpatient setting for pregnant injection opioid users with high opioid tolerance secondary to a fentanyl-based illicit drug supply.
View Article and Find Full Text PDFJ Addict Med
November 2023
From the British Columbia Centre on Substance Use, Vancouver, BC, Canada (OB, SI); Department of Medicine, University of British Columbia, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, Canada (OB, SI); Providence Health Care, Vancouver, BC, Canada (JCYN); and Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada (JCYN).
Introduction: In the midst of unprecedented opioid overdose deaths, opioid agonist therapy induction strategies that allow for rapid titration to therapeutic doses for individuals at high risk of overdose are needed. Slow release oral morphine (SROM) is an effective treatment for opioid use disorder; however, current guideline-recommended titration strategies require weeks to achieve therapeutic dose for individuals with high opioid tolerance. Individuals may be lost to care or experience overdose due to ongoing use of unregulated opioids during this time.
View Article and Find Full Text PDFFront Psychiatry
June 2022
Unit of Pharmacogenetics and Clinical Psychopharmacology, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Loperamide is an over-the-counter antidiarrheal for which increasing cases of abuse or misuse are described. We report the onset of opioid use disorder associated with low to moderate doses of loperamide in an intellectual disability patient without previous history of substance use disorder (SUD). Our patient presented strongly reduced activities of CYP3A and P-glycoprotein, which are mainly involved in loperamide metabolism and transport.
View Article and Find Full Text PDFChemosphere
August 2022
The Key Laboratory of Water and Sediment Sciences, Ministry of Education, School of Environment, Beijing Normal University, Beijing, 100875, PR China.
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