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Deep learning-driven imaging of cell division and cell growth across an entire eukaryotic life cycle.
bioRxiv
April 2024
Department of Plant and Microbial Biology, North Carolina State University.
The life cycle of biomedical and agriculturally relevant eukaryotic microorganisms involves complex transitions between proliferative and non-proliferative states such as dormancy, mating, meiosis, and cell division. New drugs, pesticides, and vaccines can be created by targeting specific life cycle stages of parasites and pathogens. However, defining the structure of a microbial life cycle often relies on partial observations that are theoretically assembled in an ideal life cycle path.
View Article and Find Full Text PDFThe G1/S repressor WHI5 is expressed at similar levels throughout the cell cycle.
BMC Res Notes
July 2022
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Objectives: While it is clear that cells need to grow before committing to division at the G1/S transition of the cell cycle, how cells sense their growth rate or size at the molecular level is unknown. It has been proposed that, in budding yeast, the dilution of the Whi5 G1/S transcriptional repressor as cells grow in G1 is the main driver of G1/S commitment. This model implies that Whi5 synthesis is substantially reduced in G1 phase.
View Article and Find Full Text PDFThe timing of Start is determined primarily by increased synthesis of the Cln3 activator rather than dilution of the Whi5 inhibitor.
Mol Biol Cell
May 2022
Molecular Systems Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG Groningen, Netherlands.
Whi5 is diluted and protein synthesis does not dramatically increase in pre- G1.
Mol Biol Cell
May 2022
Department of Biology, Stanford University, Stanford CA 94305.
Dilution and titration of cell-cycle regulators may control cell size in budding yeast.
PLoS Comput Biol
October 2018
Department of Biochemistry, University of Oxford, Oxford,United Kingdom.
The size of a cell sets the scale for all biochemical processes within it, thereby affecting cellular fitness and survival. Hence, cell size needs to be kept within certain limits and relatively constant over multiple generations. However, how cells measure their size and use this information to regulate growth and division remains controversial.
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