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Ketoprofen-induced severe toxic epidermal necrolysis associated with vanishing bile duct syndrome leading to liver transplantation.
J Dtsch Dermatol Ges
May 2022
Dermatology Unit. Azienda USL - IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Mechanistic perspective of morin protection against ketoprofen-induced gastric mucosal injury: Targeting HMGB1/RAGE/NF-κB, DJ-1/Nrf2/HO-1 and PI3K/mTOR pathways.
Arch Biochem Biophys
October 2020
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt; Department of Pharmacology and Toxicology, School of Pharmacy, NewGiza University, Giza, Egypt.
Ketoprofen is a widely used NSAID which incurs gastric mucosal damage. The high mobility group Box 1 (HMGB1) protein is a DNA-binding protein which exerts robust inflammatory actions, however, its role in ketoprofen-induced gastric damage has not been explored. Additionally, no previous studies have linked HMGB1/RAGE/NF-κB, DJ-1/Nrf2/HO-1 and PI3K/mTOR pathways in ketoprofen-induced gastropathy.
View Article and Find Full Text PDFControlled-release ketoprofen in rheumatoid arthritis and osteoarthritis: comparison of two doses in Thailand.
Clin Ther
June 1990
Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Thirty-one hospital outpatients in Thailand, 14 with rheumatoid arthritis and 17 with osteoarthritis, received 100 mg (15 patients) or 200 mg (16 patients) of controlled-release ketoprofen daily for 12 weeks. At the start of treatment, at day 42, and at day 84 (end of treatment) the patients were assessed for pain, duration and severity of morning stiffness, duration of daytime inactivity needed to produce stiffness, the duration of that stiffness, and overall clinical state. Blood and urine samples were taken to monitor hematological, renal, and carbohydrate function.
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