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http://dx.doi.org/10.3389/fgene.2022.874350 | DOI Listing |
Cancer Lett
January 2025
Clinical Trial Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Electronic address:
Neurology
January 2025
Department of Radiation Medicine and Applied Sciences, University of California, San Diego, CA.
Signal Transduct Target Ther
January 2025
National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Oxidative stress plays a crucial role in organ aging and related diseases, yet the endogenous regulators involved remain largely unknown. This work highlights the importance of metabolic homeostasis in protecting against oxidative stress in the large intestine. By developing a low-input and user-friendly pipeline for the simultaneous profiling of five distinct cysteine (Cys) states, including free SH, total Cys oxidation (Sto), sulfenic acid (SOH), S-nitrosylation (SNO), and S-glutathionylation (SSG), we shed light on Cys redox modification stoichiometries and signaling with regional resolution in the aging gut of monkeys.
View Article and Find Full Text PDFBiomolecules
November 2024
Global Health Neurology Lab, Sydney, NSW 2150, Australia.
Stroke is an often underrecognized albeit significant complication in patients with brain cancer, arising from the intricate interplay between cancer biology and cerebrovascular health. This review delves into the multifactorial pathophysiological framework linking brain cancer to elevated stroke risk, with particular emphasis on the crucial role of the neurotoxic microenvironment (NTME). The NTME, characterized by oxidative stress, neuroinflammation, and blood-brain barrier (BBB) disruption, creates a milieu that promotes and sustains vascular and neuronal injury.
View Article and Find Full Text PDFCureus
November 2024
Intensive Care Medicine, Elisabeth-Tweesteden Hospital, Tilburg, NLD.
Introduction Predatory journals are marked by inadequate editorial practices and peer review processes, diverging from established global standards in scientific publishing. This article, as a component of the ASGLOS Study, aims to explore the relationship between participant demographics and their experiences with targeted predatory business activities, including their approaches to managing daily predatory emails. Methods To collect the personal experiences of physicians' mailboxes on predatory publishing, a Google Form® survey was designed and disseminated from September 2021 to April 2022.
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