Background: The fractional amplitude of low-frequency fluctuation (fALFF) method has been underutilized in research on the pathogenesis and clinical manifestations of ocular hypertension (OH).
Purpose: This study uses resting state functional magnetic resonance imaging (rs-fMRI) and fALFF to investigate the nature of spontaneous brain activity in OH patients and the relationship, if any, between changes in activity and clinical features.
Materials And Methods: A total of 18 subjects (9 females and 9 males) with ocular hypertension (OH) and 18 healthy controls (HCs) matched for gender, age, and educational level were recruited to this study. All participants underwent an rs-fMRI scan, and spontaneous brain activity was assessed using the fALFF method. Receiver operating characteristic curves were plotted to investigate differences between OH and HC groups.
Results: The fALFF values of OH patients were significantly higher in the left precuneus lobe (LP), compared with the same region in controls ( < 0.05). Conversely, values in the left anterior cingulate lobe (LAC), were significantly lower ( < 0.05) in OH than in controls. However, no significant association was found between the mean fALFF values and clinical characteristics in either brain area.
Conclusion: High spontaneous activity in two brain areas may reflect neuropathological mechanisms underpinning visual impairment in OH patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037746 | PMC |
| http://dx.doi.org/10.3389/fmed.2021.687420 | DOI Listing |
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