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Neutrophil Percentage-to-Albumin Ratio: A Good Parameter for the Evaluation of the Severity of Anti-NMDAR Encephalitis at Admission and Prediction of Short-Term Prognosis. | LitMetric

AI Article Synopsis

  • The study aimed to explore how the neutrophil percentage-to-albumin ratio (NPAR) relates to the severity of anti-NMDAR encephalitis in patients, both at admission and discharge.
  • Researchers used various statistical methods, like logistic regression and ROC curves, to evaluate the effectiveness of NPAR in predicting disease severity and short-term outcomes.
  • Findings indicated that NPAR is a reliable indicator for assessing disease severity and prognosis, demonstrating high sensitivity and specificity in clinical settings.

Article Abstract

Objectives: The purpose of this study was to investigate the association of neutrophil percentage-to-albumin ratio (NPAR) with the severity at admission and discharge (short-term prognosis) in patients with anti-N-methyl-D-aspartic acid receptor (NMDAR) encephalitis.

Methods: Multivariable logistic regression models such as NPAR were constructed based on univariable regression results. Receiver operating characteristic (ROC) curves, nomograms, and concordance index (c-index) were used to evaluate the efficacy of the models in assessing disease severity at admission and predicting short-term prognosis, validated by bootstrap, Hosmer-Lemeshow goodness-of-fit test, calibration curves, and decision curve analysis.

Results: A total of 181 patients with anti-NMDAR encephalitis diagnosed at the First Affiliated Hospital of Zhengzhou University were included. The results showed that NPAR had good sensitivity and specificity in assessing disease severity at admission and predicting short-term prognosis. The multivariable logistic regression models based on NPAR and other influencing factors had good discrimination, consistency, accuracy, calibration ability, applicability, and validity in assessing the severity at admission and predicting short-term prognosis.

Conclusion: NPAR has good clinical value in assessing disease severity at admission and predicting short-term prognosis of patients with anti-NMDAR encephalitis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035690PMC
http://dx.doi.org/10.3389/fimmu.2022.847200DOI Listing

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