AI Article Synopsis
- This study shows the first instance of triplex DNA formation directly recognizing duplex DNA that includes the 5-methyl-2'-deoxycytosine and 2'-deoxyguanosine base pair.
- It involves the use of specially designed oligonucleotides made from an innovative artificial nucleoside called 2-amino-2'-deoxy-nebularine derivatives.
- The paper outlines their design, how they were synthesized, and their functional assessment in the context of DNA interactions.
Article Abstract
We herein demonstrated for the first time the direct recognition of duplex DNA bearing the 5-methyl-2'-deoxycytosine and 2'-deoxyguanosine base pair by triplex DNA formation. Triplex-forming oligonucleotides contained the novel artificial nucleoside analogues 2-amino-2'-deoxy-nebularine derivatives, and their molecular design, synthesis, and functional evaluation are described.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034152 | PMC |
| http://dx.doi.org/10.1039/d1ra02831f | DOI Listing |
Publication Analysis
Top Keywords
design synthesis
8
nucleoside analogues
8
triplex dna
8
duplex dna
8
dna bearing
8
base pair
8
synthesis purine
4
purine nucleoside
4
analogues formation
4
formation stable
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!