Alkaloids, secondary plant metabolites, are used in traditional medicine in many countries to treat various pathological conditions. Securinine, a unique indolizidine alkaloid combining four cycles, "6-azobicyclo[3.2.1]octane" as a key structure fused with α,β-unsaturated-γ-lactone and piperidine ring, has a broad spectrum of actions including anti-inflammatory, antibacterial, neuroprotective and antitumor, and has been previously used in medical practice. It has several reactive centers, which are double bonds at positions 12-13 and 14-15, and this is a challenging scaffold for the synthesis of biologically active compounds. In this review, works on the production of modified securinine derivatives and their biological activity are addressed. Both monovalent and bivalent derivatives that are most promising in our opinion, and have potential for further research, are considered.
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| http://dx.doi.org/10.1039/d1ra02558a | DOI Listing |
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Article Synopsis
- Recent research into mushroom-derived compounds like psilocybin and psilocin emphasizes their psychedelic effects and potential use in treating mental health issues, such as depression.
- *The study investigates how the placement of the hydroxyl group on the indole ring influences the compounds' activity at 5-HT receptors and their psychedelic-like effects, finding that compounds with hydroxyl groups in the 4th and 5th positions are more effective.
- *Simulations reveal that specific hydrogen bonds and interactions with receptor residues are critical for the compounds' effectiveness, indicating that small structural changes can significantly impact their therapeutic potential.*
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