Association between obesity during different age periods and multiple sclerosis in Saudi Arabia: A multicenter case-control study.

Neurosciences (Riyadh)

From the Department of Family and Community Medicine (Al-Wutayd), Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Department of Family and Community Medicine Department (Mohamed), King Khalid University Hospital, King Abdullah bin Abdul-Aziz University Hospital (Saeedi), Princess Nora bint Abdulrahman University, King Fahad Medical City (Al Jumah), Ministry of Health, King Abdullah International Medical Research Center-King Saud bin Abdulaziz University for Health Sciences (Al Jumah), Riyadh, and from King Fahad General Hospital (Alotaibi), Ministry of Health, Jedda, Kingdom of Saudi Arabia.

Published: April 2022

Objectives: To determine whether body size in different age periods is associated with an increased risk of MS in Saudi Arabia.

Methods: This study included 307 MS patients and 307 healthy controls from clinics and hospital wards in three cities (Riyadh, Jeddah, and Dammam) in Saudi Arabia (2016-2017). We used Stunkard's standard body silhouettes to determine the participants' body sizes (from 1 to 9) during different age periods (school levels). We calculated adjusted odds ratios (AORs) and 95% confidence intervals (CIs) and performed multivariable analysis adjusted for age and gender.

Results: Large body sizes (silhouettes 6-9) and body size 5 during intermediate school were associated with an increased risk of MS (AOR: 3.75, 95% CI: 1.10-12.78 and AOR: 3.75, 95% CI: 1.41-10, respectively). The smallest body size (1) during intermediate school was associated with a lower risk of MS (AOR: 0.39, 95% CI: 0.17-0.90) compared to body size 3.

Conclusion: Overweight and obesity during the intermediate school period (ages 13-15 years) are associated with an increased risk of MS, particularly among females.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257916PMC
http://dx.doi.org/10.17712/nsj.2022.2.20210121DOI Listing

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