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Mesna, an unusual agent causing hypersensitivity reactions during chemotherapy.
Ann Allergy Asthma Immunol
July 2022
Department of Pediatric Infectious Diseases and Immunology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address:
Retroperitoneal Liposarcoma: An Unusual Presentation of a Rare Cancer.
J Adv Pract Oncol
November 2021
Cancer Treatment Centers of America Phoenix, Goodyear, Arizona.
Retroperitoneal liposarcomas (RLPS) are rare tumors that have variable clinical behavior and complex treatment strategies based on presentation, histopathology, and genomics. Early identification is critical, and complete surgical resection remains the primary treatment, although chemotherapy and radiation are used on individual bases. Presenting symptoms are often nonspecific; therefore, a high degree of suspicion is essential for early diagnosis.
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- Coenzyme M (CoM) was previously thought to only exist in methanogenic archaea, but recent findings showed its role in bacterial propene metabolism, leading to the identification of potential CoM biosynthetic enzymes in the bacterium Py2.
- The study highlighted four putative enzymes linked to CoM production, with only one showing similarity to already known archeal counterparts, suggesting a distinct biosynthetic process in bacteria.
- Key enzymatic activities were confirmed, illustrating the initial steps of CoM biosynthesis in bacteria and paving the way for further understanding of this metabolic pathway.
Alveolar soft part sarcoma: a rare and enigmatic entity.
Clin Orthop Relat Res
September 2005
Harvard Combined Orthopaedic Oncology Program, Boston, MA 02215, USA.
Unlabelled: Alveolar soft part sarcoma is a rare malignant tumor with unusual clinical behavior. Treatment of alveolar soft part sarcoma has been difficult to evaluate because of the small numbers of cases seen, but it seemed that although treatment of the primary tumor in alveolar soft part sarcoma often is successful, treatment of metastatic tumors is unsuccessful. A review of outcome after treatment of primary and metastatic disease in the 15 patients in our database with alveolar soft part sarcoma was done in order to evaluate this issue.
View Article and Find Full Text PDFAcetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital.
Am J Kidney Dis
July 2005
Department of Medicine, Renal Division, Brigham and Women's Hospital, Boston, MA, USA.
A rare cause of high anion gap acidosis is 5-oxoproline (pyroglutamic acid), an organic acid intermediate of the gamma-glutamyl cycle. Acetaminophen and several other drugs have been implicated in the development of transient 5-oxoprolinemia in adults. We report the case of a patient with lymphoma who was admitted for salvage chemotherapy.
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