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Crosslinked Versus Non-Crosslinked Resorbable Collagen Membranes for Periodontal Regeneration: A Multicenter, Randomized, Double-Blind, Non-Inferiority Clinical Trial.
J Periodontal Res
January 2025
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Aim: This study aimed to evaluate and compare the results of combination therapy involving bone grafting and two different resorbable collagen membranes in 1-, 2- and 3-wall infrabony defects.
Methods: A total of 174 patients with infrabony defects (≥ 7 mm periodontal probing depth) were randomized to receive deproteinized bovine bone mineral (DBBM) with either a native porcine non-crosslinked collagen membrane (N-CM, control, n = 87) or a novel porcine crosslinked collagen membrane (C-CM, test, n = 87). Clinical parameters, including periodontal probing depth (PPD), clinical attachment level (CAL), and gingival recession (GR), were recorded at baseline, 12 weeks, and 24 weeks.
Developing a decision support tool to predict delayed discharge from hospitals using machine learning.
BMC Health Serv Res
January 2025
Department of Industrial Engineering, Dalhousie University, PO Box 15000, Halifax, B3H 4R2, NS, Canada.
Background: The growing demand for healthcare services challenges patient flow management in health systems. Alternative Level of Care (ALC) patients who no longer need acute care yet face discharge barriers contribute to prolonged stays and hospital overcrowding. Predicting these patients at admission allows for better resource planning, reducing bottlenecks, and improving flow.
View Article and Find Full Text PDFRed cell distribution width as a cardiovascular risk predictor in adults with hypertension in sub-Saharan Africa.
J Hum Hypertens
January 2025
Department of Pediatrics and Child Health, University of Ilorin, Ilorin, Nigeria.
Article Synopsis
- Red cell distribution width (RDW) is a measure of variability in red blood cell sizes and may indicate cardiovascular disease (CVD) risk, especially in low-resource areas, according to a study in Ghana and Nigeria.
- The study involved 319 adults with hypertension who underwent assessments like blood pressure and RDW measurement, revealing an average RDW of 13.96% and a median CVD risk score of 8.11%.
- Findings showed that RDW is positively correlated with age, systolic and diastolic blood pressure, and WHO CVD risk scores, suggesting RDW could be a useful predictor of CVD risk in this population, particularly with an RDW cutoff of >14
Circulating serum metabolites as biomarkers and predictors of residual feed intake in lactating dairy cows.
Sci Rep
January 2025
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G2P5, Canada.
Article Synopsis
- This study examines how serum metabolite profiles can help understand feed efficiency in lactating Holsteins and identify biomarkers for predicting residual feed intake (RFI).
- Comparisons were made between high and low RFI cows at different lactation stages, revealing significant differences in various metabolites, especially notable changes in early and mid-lactation.
- The findings suggest that specific metabolites, like p-Hydroxyhippuric acid and acetylornithine, could serve as effective biomarkers for predicting RFI, with models showing varying predictive accuracy across lactation stages.
Identification of cardiac wall motion abnormalities in diverse populations by deep learning of the electrocardiogram.
NPJ Digit Med
January 2025
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Cardiac wall motion abnormalities (WMA) are strong predictors of mortality, but current screening methods using Q waves from electrocardiograms (ECGs) have limited accuracy and vary across racial and ethnic groups. This study aimed to identify novel ECG features using deep learning to enhance WMA detection, referencing echocardiography as the gold standard. We collected ECG and echocardiogram data from 35,210 patients in California and labeled WMA using unstructured language parsing of echocardiographic reports.
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