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[Natural history of spinal muscular atrophy type I].

Zh Nevrol Psikhiatr Im S S Korsakova

December 2024

JSC BIOCAD, St. Petersburg, Russia.

Spinal muscular atrophy (SMA) is a group of genetically heterogeneous neuromuscular diseases characterized by the progressive loss of motor neurons in the anterior horns of the spinal cord. The prevalence of SMA is approximately 1 in 10.000 live births.

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Article Synopsis
  • - The study compares the outcomes of two gastrostomy tube placement techniques—laparoscopic (LAP) and percutaneous endoscopic (PEG)—in pediatric patients, focusing on complications and the need for additional procedures.
  • - Researchers reviewed records of 688 patients aged 0-18 who had GT placements, finding that LAP patients were generally younger and lighter than PEG patients, but both groups had similar rates of major complications.
  • - Results showed that PEG patients had a higher likelihood of developing skin infections, while no LAP placements failed during the study period, indicating potential advantages of LAP over PEG in certain aspects.
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Background: Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) using a fully covered metal stent (FCMS) or partially covered metal stent (PCMS) is performed to manage unresectable malignant biliary obstruction (MBO) following unsuccessful endoscopic retrograde cholangiopancreatography. This study aimed to compare FCMS and PCMS for EUS-HGS in patients with MBO.

Methods: We reviewed the EUS database to analyze consecutive patients with MBO who underwent EUS-HGS between November 2017 and March 2023.

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Background/objectives: This study was conducted to compare two modes of computed tomography fluoroscopy (CTF) and two gastropexy techniques used in CT-guided percutaneous radiologic gastrostomy (CT-PRG) aiming to identify the optimal techniques for image guidance and gastropexy and, thus, to overcome the current lack of consensus on the preferred modalities.

Methods: We retrospectively identified 186 successful CT-PRG procedures conducted evenly across two university hospitals from January 2019 to December 2023. Patients were divided into two groups (intermittent multislice CT biopsy mode-guided technique (MS-CT BM) and retention anchor suture (T-fastener) versus real-time (RT-)CTF and gastropexy device) for descriptive analysis of demographics, indication for PRG, radiation exposure (DLP), procedural time, number of CT scans, gastropexy time, and complications.

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American Society for Gastrointestinal Endoscopy guideline on gastrostomy feeding tubes: summary and recommendations.

Gastrointest Endosc

January 2025

Department of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, Florida, USA.

Article Synopsis
  • * It favors percutaneous endoscopic gastrostomy (PEG) over interventional radiology-guided options and recommends starting tube feeding within 4 hours post-procedure.
  • * Additionally, the guideline states that antiplatelet medications usually don’t need to be stopped before PEG, while anticoagulant management should involve a team discussion considering bleeding and cardiovascular risks.
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