AI Article Synopsis
- This research showcases a method for Markovnikov hydroalkoxylation of unactivated alkenes using alcohols through a triple catalysis involving photoredox, cobalt, and Brønsted acid catalysts under visible light.
- The process involves three main steps: generating Co(III) hydride, facilitating hydrogen atom transfer from the hydride to the alkene, and oxidizing the resulting alkyl Co(III) complex to alkyl Co(IV).
- This innovative approach enables precise control of protons and electrons, eliminating the need for strong acids and other external agents typically required in traditional methods.
Article Abstract
We demonstrate Markovnikov hydroalkoxylation of unactivated alkenes using alcohols through a triple catalysis consisting of photoredox, cobalt, and Brønsted acid catalysts under visible light irradiation. The triple catalysis realizes three key elementary steps in a single catalytic cycle: (1) Co(III) hydride generation by photochemical reduction of Co(II) followed by protonation, (2) metal hydride hydrogen atom transfer (MHAT) of alkenes by Co(III) hydride, and (3) oxidation of the alkyl Co(III) complex to alkyl Co(IV). The precise control of protons and electrons by the three catalysts allows the elimination of strong acids and external reductants/oxidants that are required in the conventional methods.
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| http://dx.doi.org/10.1021/jacs.2c00527 | DOI Listing |
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