AI Article Synopsis
- The authors propose three methods to enhance the effectiveness of immunoglobulin as a radioprotector: in vitro irradiation with gamma-quanta, extending whole blood storage time, and using immunoglobulin with antibiotics.
- In experiments, they found that combining immunoglobulin with gentamicin significantly improved its ability to kill E. coli, showing a stronger bactericidal effect than either treatment alone.
- These findings suggest potential advancements in immunoglobulin utilization, particularly in settings requiring protection against radiation and bacterial infections.
Article Abstract
In this work the authors propose three ways of increasing the radioprotective efficiency of immunoglobulin: in vitro irradiation with gamma-quanta (60Co, 20,000 Gy), increasing the time of storage of whole blood (raw material for immunoglobulin production) up to 5-7 days at +4 degrees C, and the application of immunoglobulin with antibiotics. In experiments in vitro it was first shown that a combination of immunoglobulin with gentamicin exerted a pronounced bactericidal effect on E. coli. The effect was absent with immunoglobulin and markedly less pronounced with gentamicin used separately.
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