AI Article Synopsis
- The study aimed to determine if the risk of cardiovascular disease (CVD) in women with pre-eclampsia is influenced by the birth weight of their offspring, both low and high, and if diabetes during pregnancy impacts this risk.
- The research involved a large cohort of over 618,000 women in Norway, who were monitored from childbirth until the onset of CVD or other censoring events.
- Findings revealed that women with pre-eclampsia had a significantly higher CVD risk, especially when their child was classified as large for gestational age (LGA), suggesting a connection between pre-eclampsia, LGA offspring, and increased CVD risk.
Article Abstract
Objectives: To examine whether the risk of cardiovascular disease (CVD) in women with pre-eclampsia is modified by very low or very high offspring birth weight. Further, we studied whether diabetes in pregnancy modified this risk.
Design: Nationwide cohort study.
Setting: Norwegian population registries.
Participants: 618 644 women who gave birth to their first child during 1980-2009.
Methods: The women were followed from delivery until the development of CVD or censoring, by linkage of the Medical Birth Registry of Norway to the Cardiovascular Disease in Norway project, and the Norwegian Cause of Death Registry.
Primary Outcome Measure: CVD.
Results: Compared with normotensive women with normal offspring birth weight, women with pre-eclampsia had increased risk of CVD (HR 2.16; 95% CI 2.05 to 2.26). The CVD risk was even higher when pre-eclampsia was accompanied with a large for gestational age offspring (LGA, z-score >2.0) (HR 2.57; 95% CI 2.08 to 3.18). Women with pre-eclampsia and a small for gestational age offspring (SGA, z-score <-2.0) had an HR of 1.54 (95% CI 1.23 to 1.93) compared with normotensive women with normal offspring birth weight.Also, women with diabetes had increased CVD risk, but no additional risk associated with an LGA or SGA offspring.
Conclusions: Women with pre-eclampsia and an LGA offspring had higher risk of CVD than pre-eclamptic women with a normal weight (z-score -2.0 to 2.0) or SGA offspring. These findings suggest that factors causing pre-eclampsia and an LGA offspring are also linked to development of CVD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045054 | PMC |
| http://dx.doi.org/10.1136/bmjopen-2021-055467 | DOI Listing |
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