and impact efficacy and safety of diazepam in patients with alcohol withdrawal syndrome.

Nord J Psychiatry

Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation, Moscow, Russian Federation.

Published: January 2023

AI Article Synopsis

  • Diazepam is commonly used to treat alcohol withdrawal syndrome, but some patients may not respond well or experience adverse reactions due to its metabolism involving variable enzymes (CYP3A4 and CYP3A5).
  • The study evaluated 100 male patients receiving diazepam for 5 days, focusing on two specific genetic polymorphisms and their effects on efficacy and safety.
  • Findings indicated that certain genetic variants increased the risk of adverse drug reactions and reduced the safety of diazepam therapy, suggesting that genetic testing could help optimize treatment for alcohol withdrawal.

Article Abstract

Background: Diazepam is one of the most commonly prescribed pharmaceuticals for the treatment of alcohol withdrawal syndrome (AWS). However, diazepam sometimes is ineffective, and some patients experience dose-dependent adverse drug reactions (ADR). Previous studies have shown that diazepam metabolism involves the CYP3A4 and CYP3A5 isoenzymes, whose activity is highly variable between individuals, which may contribute to differences in clinical response.

Purpose: The study aimed to investigate the effects of the genetic polymorphisms and on the efficacy and safety of diazepam in patients with AWS.

Materials And Methods: One hundred male AWS patients received 30 mg/day diazepam by intramuscular injections for 5 days. Genotyping for (rs35599367) and (rs776746) was performed by real-time polymerase chain reaction with allele-specific hybridization. The efficacy and safety assessments were performed using psychometric scales.

Results: Patients who carry and genotypes by polymorphic marker (rs35599367) of the gene had a higher risk for ADR and demonstrated lower safety of diazepam therapy ( < 0.001; two-way ANOVA).

Conclusion: These results suggest that genotyping for common CYP3A variants might have the potential to guide benzodiazepine withdrawal treatment.

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Source
http://dx.doi.org/10.1080/08039488.2022.2065531DOI Listing

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